Trainee Xander van Wijk defends thesis

Congrats go to Dr. Xander van Wijk!…for successfully defending his thesis entitled “Chemical biology of heparan sulfate: development of tools, and use of sugar analogs to inhibit heparan sulfate biosynthesis and angiogenesis.”

Three research papers related to his thesis work include:

Houben AJ*, van Wijk XM*, van Meeteren LA, van Zeijl L, van de Westerlo EM, Hausmann J, Fish A, Perrakis A, van Kuppevelt TH, Moolenaar WH. The Polybasic Insertion in Autotaxin α Confers Specific Binding to Heparin and Cell Surface Heparan Sulfate Proteoglycans. J Biol Chem. 2013 Jan 4;288(1):510-9. *equally first  PMID: 23150666

van Wijk XM, Vallen MJ, van de Westerlo EM, OosterhofA, Hao W, Versteeg EM, Raben J, Wismans RG, Smetsers TF, Dijkman HB, Schalkwijk J, van Kuppevelt TH.  ­Extraction and structural analysis of glycosaminoglycans from formalin-fixed, paraffin-embedded tissues. Glycobiology. 2012 Dec;22(12):1666-72.  PMID: 22859440

van Wijk XM, Oosterhof A, van den Broek SA, Griffioen AW, ten Dam GB, Rutjes FP, van Delft FL, van Kuppevelt TH. A 4-deoxy analogue of N-acetyl-D-glucosamine inhibits heparan sulphate expression and growth factor binding in vitro. Exp Cell Res 2010 Sep 10;316(15):2504-12.  PMID: 20433828