Hyaluronan breakdown contributes to immune defense against group A Streptococcus.

Schommer NN, Muto J, Nizet V, Gallo RL. (2014) Hyaluronan breakdown contributes to immune defense against group A Streptococcus. J Biol Chem. 289(39):26914-21. PMID: 25122767. PMCID: PMC4175332. Abstract Group A Streptococcus (GAS) commonly infects human skin and occasionally causes severe … Continued

The classical lancefield antigen of group a streptococcus is a virulence determinant with implications for vaccine design.

van Sorge NM, Cole JN, Kuipers K, Henningham A, Aziz RK, Kasirer-Friede A, Lin L, Berends ET, Davies MR, Dougan G, Zhang F, Dahesh S, Shaw L, Gin J, Cunningham M, Merriman JA, Hütter J, Lepenies B, Rooijakkers SH, Malley R, Walker MJ, Shattil SJ, Schlievert PM, Choudhury B, Nizet V. (2014) The classical lancefield antigen of group a streptococcus is a virulence determinant with … Continued

Hyaluronan digestion controls DC migration from the skin.

Muto J, Morioka Y, Yamasaki K, Kim M, Garcia A, Carlin AF, Varki A, Gallo RL. (2014) Hyaluronan digestion controls DC migration from the skin. J Clin Invest. 124(3):1309-19. PMID: 24487587; PMCID: PMC3934161 Abstract The breakdown and release of hyaluronan (HA) from the extracellular matrix has been hypothesized to act as an endogenous … Continued

Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates.

Padler-Karavani V, Hurtado-Ziola N, Chang YC, Sonnenburg JL, Ronaghy A, Yu H, Verhagen A, Nizet V, Chen X, Varki N, Varki A, Angata T. (2014) Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates. FASEB J. 28(3):1280-93. PMID: 24308974; PMCID: PMC3929681   Abstract Siglecs are sialic acid-binding Ig-like lectins that recognize sialoglycans … Continued

Demystifying heparan sulfate-protein interactions.

Xu D, Esko JD. (2014) Demystifying heparan sulfate-protein interactions. Annu Rev Biochem. 83:129-57. PMID: 24606135. Abstract Numerous proteins, including cytokines and chemokines, enzymes and enzyme inhibitors, extracellular matrix proteins, and membrane receptors, bind heparin. Although they are traditionally classified as … Continued