Publications

Project 5 Update

2016-12-01

AIM 1: We are revising a manuscript (for Cell Reports) that shows how ADAMTS9 regulates the growth of arteries. Specifically, we show, using a new gene-trap mouse allele, that ADAMTS9 is essential for matrix remodeling in the umbilical cord that is a prerequisite for differentiation...

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An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism

2016-02-04

Song, H, Qi, J., Khedri, Z., Diaz, S., Yu, H., Chen, X., Varki, A., Shi, Y., Gao, G.F.: An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism. PLoS Pathog. 2016 Jan 27;12(1):e1005411. doi: 10.1371/journal.ppat.1005411. eCollection 2016...

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Symbol Nomenclature for Graphical Representations of Glycans

2016-02-04

Varki, A., Cummings, R.D., Aebi, M., Packer, N.H., Seeberger, P.H., Esko, J.D., Stanley, P., Hart, G., Darvill, A., Kinoshita, T., Prestegard, J.J., Schnaar, R.L., Freeze, H.H., Martin, J.D., Bertozzi, C.R., Etzler, M.S., Frank, M., Vliegenthart, J.F., Lütteke, T., Perez, S., Bolton, E., Rudd, P.,...

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Human-specific Derived Alleles of CD33 and Other Genes Protect Against Post-Reproductive Cognitive Decline

2016-02-04

Schwarz, F., Springer, S., Altheide, T., Varki, N., Gagneux, P., and Varki, A.: Human-specific Derived Alleles of CD33 and Other Genes Protect Against Post-Reproductive Cognitive Decline. 2015. Proc. Nat'l. Acad. Sci. U.S.A. doi: 10.1073/pnas.1517951112.

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Immunomodulatory Activity of Extracellular Hsp70 Mediated Via Paired Receptors Siglec-5 and Siglec-14

2016-02-04

Fong, J.J., Sreedhara, K., Deng, L., Varki, N., Angata, T., Liu, Q., Nizet, V. and Varki, A.: Immunomodulatory Activity of Extracellular Hsp70 Mediated Via Paired Receptors Siglec-5 and Siglec-14. EMBO J. 2015. 34:2775-2788

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Human Siglec-9 Binds Hyaluronan to Regulate Neutrophil Activation but is Exploited by Bacterial Pathogen Mimicry

2015-09-21

Secunndino, I.,Lizcano, A., Roupe, K.M., Wang, X., Cole, J.N., Olson, J., Ali, S.R., Dahesh, S., Amayreh, L.K., Henningham, A., Varki, A. and Nizet, V.: Human Siglec-9 Binds Hyaluronan to Regulate Neutrophil Activation but is Exploited by Bacterial Pathogen Mimicry. J. Mol. Med. 2015. In press

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The multiple, complex roles of versican and its proteolytic turnover by ADAMTS proteases during embryogenesis

2015-08-28

Nandadasa S, Foulcer S, Apte SS. The multiple, complex roles of versican and its proteolytic turnover by ADAMTS proteases during embryogenesis. Matrix Biol. 2014 Apr;35:34-41. doi: 10.1016/j.matbio.2014.01.005. PMID: 24444773 Abstract Embryonic development is an exceptionally dynamic process, requiring a provisional extracellular matrix that is amenable to rapid...

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Isolation and purification of versican and analysis of versican proteolysis

2015-08-28

Foulcer SJ, Day AJ, Apte SS. Isolation and purification of versican and analysis of versican proteolysis. Methods Mol Biol. 2015;1229:587-604. doi: 10.1007/978-1-4939-1714-3_46. PMID: 25325983 Abstract Versican is a widely distributed chondroitin sulfate proteoglycan that forms large complexes with the glycosaminoglycan hyaluronan (HA). As a consequence of HA...

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Is pulmonary hypertension a metabolic disease?

2015-08-28

Barnes J, Dweik RA. Is pulmonary hypertension a metabolic disease? Am J Respir Crit Care Med. 2014 Nov 1;190(9):973-5. doi: 10.1164/rccm.201409-1702ED. PMID: 25360726 PMCID: PMC4299590

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Volatile organic compounds in bile can diagnose malignant biliary strictures in the setting of pancreatic cancer: a preliminary observation

2015-08-28

Navaneethan U, Parsi MA, Gutierrez NG, Bhatt A, Venkatesh PG, Lourdusamy D, Grove D, Hammel JP, Jang S, Sanaka MR, Stevens T, Vargo JJ,Dweik RA. Volatile organic compounds in bile can diagnose malignant biliary strictures in the setting of pancreatic cancer: a preliminary observation. Gastrointest Endosc. 2014 Dec;80(6):1038-45. doi: 10.1016/j.gie.2014.04.016. PMID: 24929484 Abstract BACKGROUND: Ascertaining the nature of biliary...

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Leptin deficiency recapitulates the histological features of pulmonary arterial hypertension in mice

2015-08-28

Aytekin M, Tonelli AR, Farver CF, Feldstein AE, Dweik RA. Leptin deficiency recapitulates the histological features of pulmonary arterial hypertension in mice. Int J Clin Exp Pathol. 2014 Apr 15;7(5):1935-46. PMID: 24966903 PMCID: PMC4069962 Abstract Leptin is a neuroendocrine peptide released by adipose tissue that enhances metabolism...

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The dietary polysaccharide maltodextrin promotes Salmonella survival and mucosal colonization in mice

2015-08-28

Nickerson KP, Homer CR, Kessler SP, Dixon LJ, Kabi A, Gordon IO, Johnson EE, de la Motte CA, McDonald C. The dietary polysaccharide maltodextrin promotes Salmonella survival and mucosal colonization in mice. PLoS One. 2014 Jul 7;9(7):e101789. doi: 10.1371/journal.pone.0101789. PMID: 25000398 PMCID: PMC4084946 Abstract In the latter half of the 20th century, societal and technological...

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Compartmentalization and Kinetics of Counterbalancing Signals in Cardiac Transplants

2015-08-27

Kaul A, Goparaju S, Dvorina N, Iida S, Keslar K, de la Motte C, Valujskik A, Fairchild R and Baldwin W. Acute and Chronic Rejection: Compartmentalization and Kinetics of Counterbalancing Signals in Cardiac Transplants. Am J Transplant. 15:333-45 (2015) PMID: 25582188 PMCID:PMC4304877 Abstract Acute and chronic rejection...

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