Publications

Hyaluronan Depolymerization by Megakaryocyte Hyaluronidase-2 Is Required for Thrombopoiesis

2017-03-23

Petrey AC, Obery DR, Kessler SP, Flamion B, de la Motte CA. Am J Pathol. 2016 Sep;186(9):2390-403. doi: 10.1016/j.ajpath.2016.05.004. PMID: 27398974 Abstract Hyaluronan is the predominant glycosaminoglycan component of the extracellular matrix with an emerging role in hematopoiesis. Modulation of hyaluronan polymer size is responsible for its control over...

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Genetic and biochemical evidence that gastrulation defects in Pofut2 mutants result from defects in ADAMTS9 secretion

2017-03-23

Benz BA, Nandadasa S, Takeuchi M, Grady RC, Takeuchi H, LoPilato RK, Kakuda S, Somerville RP, Apte SS, Haltiwanger RS, Holdener BC. Dev Biol. 2016 Aug 1;416(1):111-22. doi: 10.1016/j.ydbio.2016.05.038. PMID: 27297885 Abstract Protein O-fucosyltransferase 2 (POFUT2) adds O-linked fucose to Thrombospondin Type 1 Repeats (TSR) in 49 potential target...

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Immunoregulatory roles of versican proteolysis in the myeloma microenvironment

2017-03-23

Hope C, Foulcer S, Jagodinsky J, Chen SX, Jensen JL, Patel S, Leith C, Maroulakou I, Callander N, Miyamoto S, Hematti P, Apte SS, Asimakopoulos F. Blood. 2016 Aug 4;128(5):680-5. doi: 10.1182/blood-2016-03-705780. PMID: 27259980 Abstract Myeloma immunosurveillance remains incompletely understood. We have demonstrated proteolytic processing of the matrix proteoglycan,...

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Hyaluronidase and Hyaluronan Oligosaccharides Promote Neurological Recovery after Intraventricular Hemorrhage

2017-03-23

Vinukonda G, Dohare P, Arshad A, Zia MT, Panda S, Korumilli R, Kayton R, Hascall VC, Lauer ME, Ballabh P. J Neurosci. 2016 Jan 20;36(3):872-89. doi: 10.1523/JNEUROSCI.3297-15.2016. PMID: 26791217 Abstract Intraventricular hemorrhage (IVH) in premature infants results in inflammation, arrested oligodendrocyte progenitor cell (OPC) maturation, and reduced myelination of...

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Anti-ADAMTS5 monoclonal antibodies: implications for aggrecanase inhibition in osteoarthritis

2017-03-23

Apte SS. Biochem J. 2016 Jan 1;473(1):e1-4. doi: 10.1042/BJ20151072. Review. PMID: 26657033 Abstract The extracellular matrix of articular cartilage is structurally specialized for efficient absorption of mechanical impact. In particular, giant aggregates of the large chondroitin sulfate proteoglycan, aggrecan, with the glycosaminoglycan, hyaluronan, allow cartilage to resist compressive load....

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Hyaluronan Rafts on Airway Epithelial Cells

2017-03-23

Abbadi A, Lauer M, Swaidani S, Wang A, Hascall V. J Biol Chem. 2016 Jan 15;291(3):1448-55. doi: 10.1074/jbc.M115.704288. PMID: 26601955 Abstract Many cells, including murine airway epithelial cells, respond to a variety of inflammatory stimuli by synthesizing leukocyte-adhesive hyaluronan (HA) cables that remain attached to their cell surfaces. This...

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Hyaluronan's Role in Fibrosis: A Pathogenic Factor or a Passive Player?

2017-03-23

Albeiroti S, Soroosh A, de la Motte CA. Biomed Res Int. 2015;2015:790203. doi: 10.1155/2015/790203. Review. PMID: 26583132 Abstract Fibrosis is a debilitating condition that can lead to impairment of the affected organ's function. Excessive deposition of extracellular matrix (ECM) molecules is characteristic of most fibrotic tissues. Fibroblasts activated by...

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Hyaluronan Synthase 3 Null Mice Exhibit Decreased Intestinal Inflammation and Tissue Damage in the DSS-Induced Colitis Model

2017-03-23

Kessler SP, Obery DR, de la Motte C. Int J Cell Biol. 2015;2015:745237. doi: 10.1155/2015/745237. PMID: 26448758 Abstract Hyaluronan (HA) overproduction is a hallmark of multiple inflammatory diseases, including inflammatory bowel disease (IBD). Hyaluronan can act as a leukocyte recruitment molecule and in the most common mouse model of...

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The Rise and Fall of Hyaluronan in Respiratory Diseases

2017-03-23

Lauer ME, Dweik RA, Garantziotis S, Aronica MA. Int J Cell Biol. 2015;2015:712507. doi: 10.1155/2015/712507. Review. PMID: 26448757 Abstract In normal airways, hyaluronan (HA) matrices are primarily located within the airway submucosa, pulmonary vasculature walls, and, to a lesser extent, the alveoli. Following pulmonary injury, elevated levels of HA...

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Hyperglycemia-Induced Changes in Hyaluronan Contribute to Impaired Skin Wound Healing in Diabetes: Review and Perspective

2017-03-23

Shakya S, Wang Y, Mack JA, Maytin EV. Int J Cell Biol. 2015;2015:701738. doi: 10.1155/2015/701738. Review. PMID: 26448756 Abstract Ulcers and chronic wounds are a particularly common problem in diabetics and are associated with hyperglycemia. In this targeted review, we summarize evidence suggesting that defective wound healing in diabetics...

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Utilization of Glycosaminoglycans/Proteoglycans as Carriers for Targeted Therapy Delivery

2017-03-23

Misra S, Hascall VC, Atanelishvili I, Moreno Rodriguez R, Markwald RR, Ghatak S. Int J Cell Biol. 2015;2015:537560. doi: 10.1155/2015/537560. Review. PMID: 26448753 Abstract The outcome of patients with cancer has improved significantly in the past decade with the incorporation of drugs targeting cell surface adhesive receptors, receptor tyrosine...

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ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis

2017-03-23

Janssen L, Dupont L, Bekhouche M, Noel A, Leduc C, Voz M, Peers B, Cataldo D, Apte SS, Dubail J, Colige A. Angiogenesis. 2016 Jan;19(1):53-65. doi: 10.1007/s10456-015-9488-z. PMID: 26446156 Abstract The only documented activity of a subclass of ADAMTS proteases comprising ADAMTS2, 3 and 14 is the cleavage of...

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The Responses of Hyperglycemic Dividing Mesangial Cells to Heparin Are Mediated by the Non-reducing Terminal Trisaccharide

2017-03-23

Wang CP, Hascall VC, Zhang F, Linhardt RJ, Abbadi A, Wang A. J Biol Chem. 2015 Nov 27;290(48):29045-50. doi: 10.1074/jbc.M115.677401. PMID: 26378235 Abstract Our previous studies showed: (i) that growth-arrested G0/G1 rat mesangial cells stimulated to divide in hyperglycemic medium initiate intracellular hyaluronan synthesis that induces autophagy and the...

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