Publications

Tumorigenic potential is restored during differentiation in fusion-reprogrammed cancer cells

2017-04-06

Yao J, Zhang L, Hu L, Guo B, Hu X, Borjigin U, Wei Z, Chen Y, Lv M, Lau JT, Wang X, Li G, Hu YP. Cell Death Dis. 2016 Jul 28;7(7):e2314. doi: 10.1038/cddis.2016.189. PMID: 27468690 Abstract Detailed understanding of the mechanistic steps underlying tumor initiation and malignant progression...

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Glycoengineering of E-Selectin Ligands by Intracellular versus Extracellular Fucosylation Differentially Affects Osteotropism of Human Mesenchymal Stem Cells

2017-04-06

Dykstra B, Lee J, Mortensen LJ, Yu H, Wu ZL, Lin CP, Rossi DJ, Sackstein R. Stem Cells. 2016 Oct;34(10):2501-2511. doi: 10.1002/stem.2435. PMID: 27335219 Abstract Human mesenchymal stem cells (MSCs) hold great promise in cellular therapeutics for skeletal diseases but lack expression of E-selectin ligands that direct homing of...

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Platelet clearance by the hepatic Ashwell-Morrell receptor: mechanisms and biological significance

2017-04-06

Hoffmeister KM, Falet H. Thromb Res. 2016 May;141 Suppl 2:S68-72. doi: 10.1016/S0049-3848(16)30370-X. PMID: 27207430 Abstract The daily production of billions of platelets must be regulated to avoid spontaneous bleeding or arterial occlusion and organ damage. Complex mechanisms control platelet production and clearance in physiological and pathological conditions. This review...

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Glycans and the platelet life cycle

2017-04-06

Li R, Hoffmeister KM, Falet H. Platelets. 2016 Sep;27(6):505-11. doi: 10.3109/09537104.2016.1171304. PMID: 27135356 Abstract Platelet numbers are intricately regulated to avoid spontaneous bleeding or arterial occlusion and organ damage. The growth factor thrombopoietin (TPO) drives platelet biogenesis by inducing megakaryocyte production. A recent study in mice identified a feedback...

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Fulfilling Koch's postulates in glycoscience: HCELL, GPS and translational glycobiology

2017-04-06

Sackstein R. Glycobiology. 2016 Jun;26(6):560-70. doi: 10.1093/glycob/cww026. Review. PMID: 26933169 Abstract Glycoscience-based research that is performed expressly to address medical necessity and improve patient outcomes is called "translational glycobiology". In the 19th century, Robert Koch proposed a set of postulates to rigorously establish causality in microbial pathogenesis, and these...

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Regulating billions of blood platelets: glycans and beyond

2017-04-06

Grozovsky R, Giannini S, Falet H, Hoffmeister KM. Blood. 2015 Oct 15;126(16):1877-84. doi: 10.1182/blood-2015-01-569129. Review. PMID: 26330242 Abstract The human body produces and removes 10(11) platelets daily to maintain a normal steady state platelet count. Platelet production must be regulated to avoid spontaneous bleeding or arterial occlusion and organ...

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2015 proceedings of the National Heart, Lung, and Blood Institute's State of the Science in Transfusion Medicine symposium.

2017-04-06

Spitalnik SL, Triulzi D, Devine DV, Dzik WH, Eder AF, Gernsheimer T, Josephson CD, Kor DJ, Luban NL, Roubinian NH, Mondoro T, Welniak LA, Zou S, Glynn S; State of the Science in Transfusion Medicine Working Groups.. Transfusion. 2015 Sep;55(9):2282-90. doi: 10.1111/trf.13250. PMID: 26260861 Abstract On March 25 and...

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Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia

2017-04-06

Li J, van der Wal DE, Zhu G, Xu M, Yougbare I, Ma L, Vadasz B, Carrim N, Grozovsky R, Ruan M, Zhu L, Zeng Q, Tao L, Zhai ZM, Peng J, Hou M, Leytin V, Freedman J, Hoffmeister KM, Ni H. Nat Commun. 2015 Jul...

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Novel mechanisms of platelet clearance and thrombopoietin regulation

2017-04-06

Grozovsky R, Giannini S, Falet H, Hoffmeister KM. Curr Opin Hematol. 2015 Sep;22(5):445-51. doi: 10.1097/MOH.0000000000000170. Review. PMID: 26154508 Abstract PURPOSE OF REVIEW: The human body produces and removes 10 platelets daily to maintain a normal steady-state platelet count. Platelet production must be tightly regulated to avoid spontaneous bleeding or arterial...

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Cell surface glycan engineering of neural stem cells augments neurotropism and improves recovery in a murine model of multiple scleros

2017-04-06

Merzaban JS, Imitola J, Starossom SC, Zhu B, Wang Y, Lee J, Ali AJ, Olah M, Abuelela AF, Khoury SJ, Sackstein R. Glycobiology. 2015 Dec;25(12):1392-409. doi: 10.1093/glycob/cwv046. PMID: 26153105 Abstract Neural stem cell (NSC)-based therapies offer potential for neural repair in central nervous system (CNS) inflammatory and degenerative disorders....

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Progress and obstacles towards generating hematopoietic stem cells from pluripotent stem cells

2017-04-06

Lee J, Dykstra B, Sackstein R, Rossi DJ. Curr Opin Hematol. 2015 Jul;22(4):317-23. doi: 10.1097/MOH.0000000000000147. Review. PMID: 26049752 Abstract PURPOSE OF REVIEW: Human pluripotent stem cells (PSCs) have the potential to provide an inexhaustible source of hematopoietic stem cells (HSCs) that could be used in disease modeling and in clinical...

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Integration of systems glycobiology with bioinformatics toolboxes, glycoinformatics resources, and glycoproteomics data

2017-04-06

Liu G, Neelamegham S. Wiley Interdiscip Rev Syst Biol Med. 2015 Jul-Aug;7(4):163-81. doi: 10.1002/wsbm.1296. Review. PMID: 25871730 Abstract The glycome constitutes the entire complement of free carbohydrates and glycoconjugates expressed on whole cells or tissues. 'Systems Glycobiology' is an emerging discipline that aims to quantitatively describe and analyse the...

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FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets

2017-04-06

Begonja AJ, Pluthero FG, Suphamungmee W, Giannini S, Christensen H, Leung R, Lo RW, Nakamura F, Lehman W, Plomann M, Hoffmeister KM, Kahr WH, Hartwig JH, Falet H. Blood. 2015 Jul 2;126(1):80-8. doi: 10.1182/blood-2014-07-587600. PMID: 25838348 Abstract Bin-Amphiphysin-Rvs (BAR) and Fes-CIP4 homology BAR (F-BAR) proteins generate tubular membrane invaginations...

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