Gangliosides of the Vertebrate Nervous System

Schnaar RL. J Mol Biol. 2016 Aug 14;428(16):3325-36. doi: 10.1016/j.jmb.2016.05.020. Review. PMID: 27261254 Abstract Gangliosides, sialylated glycosphingolipids, found on all vertebrate cells and tissues, are major molecular determinants on the surfaces of vertebrate nerve cells. Composed of a sialylated glycan attached to … Continued

Glycobiology simplified: diverse roles of glycan recognition in inflammation

Schnaar RL. J Leukoc Biol. 2016 Jun;99(6):825-38. doi: 10.1189/jlb.3RI0116-021R. Review. PMID: 27004978 Abstract Glycans and complementary glycan-binding proteins are essential components in the language of cell-cell interactions in immunity. The study of glycan function is the purview of glycobiology, which has often … Continued

“Siglec”ting the allergic response for therapeutic targeting

Bochner BS. Glycobiology. 2016 Jun;26(6):546-52. doi: 10.1093/glycob/cww024. Review. PMID: 26911285 Abstract As a physician-scientist, I have pursued research related to translational immunology with the goal of improving our ability to diagnose and treat allergic, immunologic and other diseases involving eosinophils, basophils and … Continued

Regulation of airway inflammation by Siglec-8 and Siglec-9 sialoglycan ligand expression

Schleimer RP, Schnaar RL, Bochner BS. Curr Opin Allergy Clin Immunol. 2016 Feb;16(1):24-30. doi: 10.1097/ACI.0000000000000234. Review. PMID: 26694037 Abstract PURPOSE OF REVIEW: Inflammatory cells involved in the allergic response, including eosinophils, mast cells, basophils, and neutrophils, express sialoglycan-binding proteins such as Siglec-8 … Continued

Therapeutic Targeting of Siglecs using Antibody- and Glycan-Based Approaches

Angata T, Nycholat CM, Macauley MS. Trends Pharmacol Sci. 2015 Oct;36(10):645-60. doi: 10.1016/j.tips.2015.06.008. Review. PMID: 26435210 Abstract The sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of immunomodulatory receptors whose functions are regulated by their glycan ligands. Siglecs are attractive therapeutic targets … Continued

Novel Therapies for Eosinophilic Disorders

Bochner BS.Immunol Allergy Clin North Am. 2015 Aug;35(3):577-98. doi: 10.1016/j.iac.2015.05.007. Review. PMID: 26209901 Abstract Current therapies for eosinophilic disorders are limited. Most treatment approaches remain empirical, are not supported by data from controlled clinical trials, involve the off-label use of agents … Continued