Determinants of versican-V1 proteoglycan processing by the metalloproteinase ADAMTS5.

Foulcer SJ, Nelson CM, Quintero MV, Kuberan B, Larkin J, Dours-Zimmermann MT, Zimmermann DR, Apte SS. (2014) Determinants of versican-V1 proteoglycan processing by the metalloproteinase ADAMTS5. J Biol Chem. 289(40):27859-73. PMID: 25122765. PMCID: PMC4183820. Abstract Proteolysis of the Glu(441)-Ala(442) bond … Continued

Substantial non-electrostatic forces are needed to induce allosteric disruption of thrombin’s active site through exosite 2

Mehta AY, Desai UR. (2014) Substantial non-electrostatic forces are needed to induce allosteric disruption of thrombin’s active site through exosite 2. PMID: 25201728. PMCID: PMC4179500. Abstract Sulfated β-O4 lignin (SbO4L), a non-saccharide glycosaminoglycan mimetic, was recently disclosed as a novel … Continued

Sulfated low molecular weight lignins, allosteric inhibitors of coagulation proteinases via the heparin binding site, significantly alter the active site of thrombin and factor xa compared to heparin.

Henry BL, Desai UR. (2014) Sulfated low molecular weight lignins, allosteric inhibitors of coagulation proteinases via the heparin binding site, significantly alter the active site of thrombin and factor xa compared to heparin. Thromb Res. 134(5):1123-9. PMID: 25242245. PMCID: PMC4253681. … Continued

Progress in pig-to-non-human primate transplantation models (1998-2013): a comprehensive review of the literature.

Cooper DK, Satyananda V, Ekser B, van der Windt DJ, Hara H, Ezzelarab MB, Schuurman HJ. (2014) Progress in pig-to-non-human primate transplantation models (1998-2013): a comprehensive review of the literature. Xenotransplantation. 21(5):397-419. PMID: 25176336. PMCID: PMC4176554. Abstract BACKGROUND: The pig-to-non-human … Continued

Polyunsaturated fatty acyl-coenzyme As are inhibitors of cholesterol biosynthesis in zebrafish and mice.

Karanth S, Tran VM, Kuberan B, Schlegel A. (2013) Polyunsaturated fatty acyl-coenzyme As are inhibitors of cholesterol biosynthesis in zebrafish and mice. Dis Model Mech. 6(6):1365-77. PMID: 24057001; PMCID: PMC3820260 Abstract Lipid disorders pose therapeutic challenges. Previously we discovered that mutation of the hepatocyte β-hydroxybutyrate transporter Slc16a6a in zebrafish … Continued

The role of platelets in coagulation dysfunction in xenotransplantation, and therapeutic options.

Iwase H, Ezzelarab MB, Ekser B, Cooper DK. (2014) The role of platelets in coagulation dysfunction in xenotransplantation, and therapeutic options. Xenotransplantation. 2014 May-Jun;21(3):201-20. PMID: 24571124. Abstract Xenotransplantation could resolve the increasing discrepancy between the availability of deceased human donor … Continued

Designing Allosteric Inhibitors of Factor XIa. Lessons from the Interactions of Sulfated Pentagalloylglucopyranosides.

Al-Horani RA, Desai UR. (2014) Designing Allosteric Inhibitors of Factor XIa. Lessons from the Interactions of Sulfated Pentagalloylglucopyranosides. J Med Chem. 57(11):4805-18. PMID: 24844380. Abstract We recently introduced sulfated pentagalloylglucopyranoside (SPGG) as an allosteric inhibitor of factor XIa (FXIa) (Al-Horani … Continued

Increased soluble CD154 (CD40 ligand) levels in xenograft recipients correlate with the development of de novo anti-pig IgG antibodies

Ezzelarab MB1, Ekser B, Isse K, Iwase H, Morelli AE, Ayares D, Cooper DK. (2014) Increased soluble CD154 (CD40 ligand) levels in xenograft recipients correlate with the development of de novo anti-pig IgG antibodies. Transplantation. 97(5):502-8. PMID: 244879395 Abstract BACKGROUND: De novo anti-pig antibodies are associated with acute humoral xenograft … Continued