Chemogenesis of an antiangiogenic glycosaminoglycan.

Raman K, Arungundram S, Kuberan B. (2014) Chemogenesis of an antiangiogenic glycosaminoglycan. ACS Med Chem Lett. 5(6):644-6. PMID: 24944736. PMCID: PMC4060934.

Abstract

In this letter we report a facile chemical conversion of heparin, a potent anticoagulant with minimal antiangiogenic activity, into an effective antiangiogenic glycosaminoglycan through optimized chemical approaches. This work highlights the potential for industrial scale production of a therapeutic anticancer glycosaminoglycan.

Keywords

Acharan sulfate; angiogenesis; heparan sulfate; heparin; synthesis

Link to journal: http://pubs.acs.org/journal/amclct