Thyroid hormone: relevance to xenotransplantation

Iwase H, Ekser B, Hara H, Ezzelarab MB, Long C, Thomson AW, Ayares D, Cooper DK. Xenotransplantation. 2016 Jul;23(4):293-9. doi: 10.1111/xen.12243. PMID: 27374212 Abstract BACKGROUND: It has been well documented that the level of serum/plasma free triiodothyronine (fT3) falls rapidly following brain … Continued

Luminal Extracellular Vesicles (EVs) in Inflammatory Bowel Disease (IBD) Exhibit Proinflammatory Effects on Epithelial Cells and Macrophages

Mitsuhashi S, Feldbrügge L, Csizmadia E, Mitsuhashi M, Robson SC, Moss AC. Inflamm Bowel Dis. 2016 Jul;22(7):1587-95. doi: 10.1097/MIB.0000000000000840. PMID: 27271497 Abstract BACKGROUND: Extracellular vesicles (EVs) are membrane-enclosed particles released by cells as a means of intercellular communication. They are potential novel … Continued

Factor XIa inhibitors: A review of the patent literature

Al-Horani RA, Desai UR. Expert Opin Ther Pat. 2016;26(3):323-45. doi: 10.1517/13543776.2016.1154045. Review. PMID: 26881476 Abstract INTRODUCTION: Anticoagulants are the mainstay for prevention and/or treatment of thrombotic disorders. Each clinically used anticoagulant is associated with significant adverse consequences, especially bleeding. Factor XIa (FXIa), … Continued

Allosterism-based simultaneous, dual anticoagulant and antiplatelet action: allosteric inhibitor targeting the glycoprotein Ibα-binding and heparin-binding site of thrombin

Mehta AY, Mohammed BM, Martin EJ, Brophy DF, Gailani D, Desai UR. J Thromb Haemost. 2016 Apr;14(4):828-38. doi: 10.1111/jth.13254. PMID: 26748875 Abstract BACKGROUND: Allosteric inhibition is a promising approach for developing a new group of anticoagulants with potentially reduced bleeding consequences. Recently, … Continued

CXCL1/MGSA Is a Novel Glycosaminoglycan (GAG)-binding Chemokine: STRUCTURAL EVIDENCE FOR TWO DISTINCT NON-OVERLAPPING BINDING DOMAINS

Sepuru KM, Rajarathnam K. J Biol Chem. 2016 Feb 19;291(8):4247-55. doi: 10.1074/jbc.M115.697888. PMID: 26721883 Abstract In humans, the chemokine CXCL1/MGSA (hCXCL1) plays fundamental and diverse roles in pathophysiology, from microbial killing to cancer progression, by orchestrating the directed migration of immune and … Continued

A Simple Method for Discovering Druggable, Specific Glycosaminoglycan-Protein Systems. Elucidation of Key Principles from Heparin/Heparan Sulfate-Binding Proteins

Sarkar A, Desai UR. PLoS One. 2015 Oct 21;10(10):e0141127. doi: 10.1371/journal.pone.0141127. PMID: 26488293 Abstract Glycosaminoglycans (GAGs) affect human physiology and pathology by modulating more than 500 proteins. GAG-protein interactions are generally assumed to be ionic and nonspecific, but specific interactions do exist. … Continued