Publications

Hyaluronan Depolymerization by Megakaryocyte Hyaluronidase-2 Is Required for Thrombopoiesis

Petrey AC, Obery DR, Kessler SP, Flamion B, de la Motte CA. Am J Pathol. 2016 Sep;186(9):2390-403. doi: 10.1016/j.ajpath.2016.05.004. PMID: 27398974 Abstract Hyaluronan is the predominant glycosaminoglycan component of the extracellular matrix with an emerging role in hematopoiesis. Modulation of hyaluronan polymer … Continued

Genetic and biochemical evidence that gastrulation defects in Pofut2 mutants result from defects in ADAMTS9 secretion

Benz BA, Nandadasa S, Takeuchi M, Grady RC, Takeuchi H, LoPilato RK, Kakuda S, Somerville RP, Apte SS, Haltiwanger RS, Holdener BC. Dev Biol. 2016 Aug 1;416(1):111-22. doi: 10.1016/j.ydbio.2016.05.038. PMID: 27297885 Abstract Protein O-fucosyltransferase 2 (POFUT2) adds O-linked fucose to Thrombospondin Type … Continued

Immunoregulatory roles of versican proteolysis in the myeloma microenvironment

Hope C, Foulcer S, Jagodinsky J, Chen SX, Jensen JL, Patel S, Leith C, Maroulakou I, Callander N, Miyamoto S, Hematti P, Apte SS, Asimakopoulos F. Blood. 2016 Aug 4;128(5):680-5. doi: 10.1182/blood-2016-03-705780. PMID: 27259980 Abstract Myeloma immunosurveillance remains incompletely understood. We have … Continued

Hyaluronidase and Hyaluronan Oligosaccharides Promote Neurological Recovery after Intraventricular Hemorrhage

Vinukonda G, Dohare P, Arshad A, Zia MT, Panda S, Korumilli R, Kayton R, Hascall VC, Lauer ME, Ballabh P. J Neurosci. 2016 Jan 20;36(3):872-89. doi: 10.1523/JNEUROSCI.3297-15.2016. PMID: 26791217 Abstract Intraventricular hemorrhage (IVH) in premature infants results in inflammation, arrested oligodendrocyte progenitor … Continued

Anti-ADAMTS5 monoclonal antibodies: implications for aggrecanase inhibition in osteoarthritis

Apte SS. Biochem J. 2016 Jan 1;473(1):e1-4. doi: 10.1042/BJ20151072. Review. PMID: 26657033 Abstract The extracellular matrix of articular cartilage is structurally specialized for efficient absorption of mechanical impact. In particular, giant aggregates of the large chondroitin sulfate proteoglycan, aggrecan, with the glycosaminoglycan, … Continued

Hyaluronan Rafts on Airway Epithelial Cells

Abbadi A, Lauer M, Swaidani S, Wang A, Hascall V. J Biol Chem. 2016 Jan 15;291(3):1448-55. doi: 10.1074/jbc.M115.704288. PMID: 26601955 Abstract Many cells, including murine airway epithelial cells, respond to a variety of inflammatory stimuli by synthesizing leukocyte-adhesive hyaluronan (HA) cables that … Continued

Hyaluronan’s Role in Fibrosis: A Pathogenic Factor or a Passive Player?

Albeiroti S, Soroosh A, de la Motte CA. Biomed Res Int. 2015;2015:790203. doi: 10.1155/2015/790203. Review. PMID: 26583132 Abstract Fibrosis is a debilitating condition that can lead to impairment of the affected organ’s function. Excessive deposition of extracellular matrix (ECM) molecules is characteristic … Continued

Hyaluronan Synthase 3 Null Mice Exhibit Decreased Intestinal Inflammation and Tissue Damage in the DSS-Induced Colitis Model

Kessler SP, Obery DR, de la Motte C. Int J Cell Biol. 2015;2015:745237. doi: 10.1155/2015/745237. PMID: 26448758 Abstract Hyaluronan (HA) overproduction is a hallmark of multiple inflammatory diseases, including inflammatory bowel disease (IBD). Hyaluronan can act as a leukocyte recruitment molecule and … Continued

The Rise and Fall of Hyaluronan in Respiratory Diseases

Lauer ME, Dweik RA, Garantziotis S, Aronica MA. Int J Cell Biol. 2015;2015:712507. doi: 10.1155/2015/712507. Review. PMID: 26448757 Abstract In normal airways, hyaluronan (HA) matrices are primarily located within the airway submucosa, pulmonary vasculature walls, and, to a lesser extent, the alveoli. … Continued

Hyperglycemia-Induced Changes in Hyaluronan Contribute to Impaired Skin Wound Healing in Diabetes: Review and Perspective

Shakya S, Wang Y, Mack JA, Maytin EV. Int J Cell Biol. 2015;2015:701738. doi: 10.1155/2015/701738. Review. PMID: 26448756 Abstract Ulcers and chronic wounds are a particularly common problem in diabetics and are associated with hyperglycemia. In this targeted review, we summarize evidence … Continued

Utilization of Glycosaminoglycans/Proteoglycans as Carriers for Targeted Therapy Delivery

Misra S, Hascall VC, Atanelishvili I, Moreno Rodriguez R, Markwald RR, Ghatak S. Int J Cell Biol. 2015;2015:537560. doi: 10.1155/2015/537560. Review. PMID: 26448753 Abstract The outcome of patients with cancer has improved significantly in the past decade with the incorporation of drugs … Continued

ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis

Janssen L, Dupont L, Bekhouche M, Noel A, Leduc C, Voz M, Peers B, Cataldo D, Apte SS, Dubail J, Colige A. Angiogenesis. 2016 Jan;19(1):53-65. doi: 10.1007/s10456-015-9488-z. PMID: 26446156 Abstract The only documented activity of a subclass of ADAMTS proteases comprising ADAMTS2, … Continued

The Responses of Hyperglycemic Dividing Mesangial Cells to Heparin Are Mediated by the Non-reducing Terminal Trisaccharide

Wang CP, Hascall VC, Zhang F, Linhardt RJ, Abbadi A, Wang A. J Biol Chem. 2015 Nov 27;290(48):29045-50. doi: 10.1074/jbc.M115.677401. PMID: 26378235 Abstract Our previous studies showed: (i) that growth-arrested G0/G1 rat mesangial cells stimulated to divide in hyperglycemic medium initiate intracellular … Continued

Hyaluronan and Its Heavy Chain Modification in Asthma Severity and Experimental Asthma Exacerbation

Lauer ME, Majors AK, Comhair S, Ruple LM, Matuska B, Subramanian A, Farver C, Dworski R, Grandon D, Laskowski D, Dweik RA, Erzurum SC, Hascall VC, Aronica MA. J Biol Chem. 2015 Sep 18;290(38):23124-34. doi: 10.1074/jbc.M115.663823. PMID: 26209637 Abstract Hyaluronan (HA) is … Continued

Elevated pulmonary pressure: A novel risk marker in kidney disease?

Navaneethan SD, Dweik RA. Kidney Int. 2015 Jul;88(1):7-9. doi: 10.1038/ki.2015.111. PMID: 26126087 Abstract Pulmonary hypertension is associated with adverse cardiac outcomes and death in the general population. Bolignano and colleagues studied the prevalence of higher estimated pulmonary artery systolic pressure (⩾35 mm Hg) assessed … Continued

ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation

Nandadasa S, Nelson CM, Apte SS. Cell Rep. 2015 Jun 16;11(10):1519-28. doi: 10.1016/j.celrep.2015.05.005. PMID: 26027930 Abstract Despite the significance for fetal nourishment in mammals, mechanisms of umbilical cord vascular growth remain poorly understood. Here, the secreted metalloprotease ADAMTS9 is shown to be … Continued

Outcomes of β-blocker use in pulmonary arterial hypertension: a propensity-matched analysis

Bandyopadhyay D, Bajaj NS, Zein J, Minai OA, Dweik RA. Eur Respir J. 2015 Sep;46(3):750-60. doi: 10.1183/09031936.00215514. PMID: 26022959 Abstract The utility and safety of β-blockers in pulmonary hypertension is controversial. Anecdotal reports suggest that β-blockers may be harmful in these patients. … Continued

Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer

Misra S, Hascall VC, Markwald RR, Ghatak S. Front Immunol. 2015 May 6;6:201. doi: 10.3389/fimmu.2015.00201. Review. PMID: 25999946 Abstract The glycosaminoglycan hyaluronan (HA), a major component of extracellular matrices, and cell surface receptors of HA have been proposed to have pivotal roles … Continued

The role of hyaluronan in innate defense responses of the intestine

de la Motte CA, Kessler SP. Int J Cell Biol. 2015;2015:481301. doi: 10.1155/2015/481301. Review. PMID: 25922605 Abstract Hyaluronan is an abundant extracellular matrix component prevalent in the vertebrate intestinal tract. Here we discuss what is known about hyaluronan distribution during homeostasis and … Continued

Analysis of breath volatile organic compounds in children with chronic liver disease compared to healthy controls

Eng K, Alkhouri N, Cikach F, Patel N, Yan C, Grove D, Lopez R, Rome E, Dweik RA. J Breath Res. 2015 Apr 20;9(2):026002. doi: 10.1088/1752-7155/9/2/026002. PMID: 25891513 Abstract Breath testing is increasingly being used as a non-invasive diagnostic tool for disease … Continued

The epithelial danger signal IL-1α is a potent activator of fibroblasts and reactivator of intestinal inflammation

Scarpa M, Kessler S, Sadler T, West G, Homer C, McDonald C, de la Motte C, Fiocchi C, Stylianou E. Am J Pathol. 2015 Jun;185(6):1624-37. doi: 10.1016/j.ajpath.2015.02.018. PMID: 25864926 Abstract Intestinal epithelial cell (IEC) death is typical of inflammatory bowel disease (IBD). … Continued

Deletion of ADAMTS5 does not affect aggrecan or versican degradation but promotes glucose uptake and proteoglycan synthesis in murine adipose derived stromal cells

Gorski DJ, Xiao W, Li J, Luo W, Lauer M, Kisiday J, Plaas A, Sandy J. Matrix Biol. 2015 Sep;47:66-84. doi: 10.1016/j.matbio.2015.03.008. PMID: 25840345 Abstract ADAMTS5 (TS5), a member of the aggrecanase clade (TS1, 4, 5, 8, 9, 15) of ADAMTS-proteases, has … Continued

Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics

Dubail J, Apte SS. Matrix Biol. 2015 May-Jul;44-46:24-37. doi: 10.1016/j.matbio.2015.03.001. Review. PMID: 25770910 Abstract The mammalian ADAMTS superfamily comprises 19 secreted metalloproteinases and 7 ADAMTS-like proteins, each the product of a distinct gene. Thus far, all appear to be relevant to extracellular … Continued

Shot-noise limited Faraday rotation spectroscopy for detection of nitric oxide isotopes in breath, urine, and blood

Wang Y, Nikodem M, Zhang E, Cikach F, Barnes J, Comhair S, Dweik RA, Kao C, Wysocki G. Sci Rep. 2015 Mar 13;5:9096. doi: 10.1038/srep09096. PMID: 25767064 Abstract Measurement of NO and/or its metabolites in the various body compartments has transformed our … Continued

Volatile Organic Compounds in Urine for Noninvasive Diagnosis of Malignant Biliary Strictures: A Pilot Study

Navaneethan U, Parsi MA, Lourdusamy D, Grove D, Sanaka MR, Hammel JP, Vargo JJ, Dweik RA. Dig Dis Sci. 2015 Jul;60(7):2150-7. doi: 10.1007/s10620-015-3596-x. PMID: 25708900 Abstract BACKGROUND: The use of volatile organic compounds (VOCs) in bile was recently studied and appeared promising … Continued

Chromosome-associated protein D3 promotes bacterial clearance in human intestinal epithelial cells by repressing expression of amino acid transporters

Schuster AT, Homer CR, Kemp JR, Nickerson KP, Deutschman E, Kim Y, West G, Sadler T, Stylianou E, Krokowski D, Hatzoglou M, de la Motte C, Rubin BP, Fiocchi C, McDonald C, Longworth MS. Gastroenterology. 2015 Jun;148(7):1405-16.e3. doi: 10.1053/j.gastro.2015.02.013. PMID: 25701737 Abstract … Continued

Hyperglycemia diverts dividing stem cells to pathological adipogenesis

Hascall V, Wang A. Stem Cell Res Ther. 2014 Nov 17;5(6):128. doi: 10.1186/scrt518. PMID: 25689074 Abstract This commentary proposes a mechanism for why murine diabetic adipose tissue contains very few remaining stem cells compared with normal adipose tissue. The mechanism involves the … Continued

O-linked β-N-acetylglucosamine transferase directs cell proliferation in idiopathic pulmonary arterial hypertension

Barnes JW, Tian L, Heresi GA, Farver CF, Asosingh K, Comhair SA, Aulak KS, Dweik RA. Circulation. 2015 Apr 7;131(14):1260-8. doi: 10.1161/CIRCULATIONAHA.114.013878. PMID: 25663381 Abstract BACKGROUND: Idiopathic pulmonary arterial hypertension (IPAH) is a cardiopulmonary disease characterized by cellular proliferation and vascular remodeling. … Continued

Are transcutaneous oxygen and carbon dioxide determinations of value in pulmonary arterial hypertension?

Tonelli AR, Alkukhun L, Cikach F, Ahmed M, Dweik RA. Microcirculation. 2015 May;22(4):249-56. doi: 10.1111/micc.12191. PMID: 25641509 Abstract BACKGROUND: We hypothesized that transcutaneous gas determinations of O2 and CO2 (TcPO2 and TcPCO2 ) are associated with the severity of PAH. METHODS: In … Continued

Determination of hyaluronan molecular mass distribution in human breast milk

Yuan H, Amin R, Ye X, de la Motte CA, Cowman MK. Anal Biochem. 2015 Apr 1;474:78-88. doi: 10.1016/j.ab.2014.12.020. PMID: 25579786 Abstract Hyaluronan (HA) in human milk mediates host responses to microbial infection via TLR4- and CD44-dependent signaling. Signaling by HA is … Continued

Review article: breath analysis in inflammatory bowel diseases

Kurada S, Alkhouri N, Fiocchi C, Dweik R, Rieder F. Aliment Pharmacol Ther. 2015 Feb;41(4):329-41. doi: 10.1111/apt.13050. Review. PMID: 25523187 Abstract BACKGROUND: There is an urgent need for cheap, reproducible, easy to perform and specific biomarkers for diagnosis, differentiation and stratification of … Continued

Volatile organic compounds in bile for early diagnosis of cholangiocarcinoma in patients with primary sclerosing cholangitis: a pilot study

Navaneethan U, Parsi MA, Lourdusamy V, Bhatt A, Gutierrez NG, Grove D, Sanaka MR, Hammel JP, Stevens T, Vargo JJ, Dweik RA. Gastrointest Endosc. 2015 Apr;81(4):943-9.e1. doi: 10.1016/j.gie.2014.09.041. PMID: 25500329 Abstract BACKGROUND: The diagnosis of cholangiocarcinoma (CCA) in patients with primary sclerosing … Continued

Platelet hyaluronidase-2: an enzyme that translocates to the surface upon activation to function in extracellular matrix degradation

Albeiroti S, Ayasoufi K, Hill DR, Shen B, de la Motte CA. Blood. 2015 Feb 26;125(9):1460-9. doi: 10.1182/blood-2014-07-590513. PMID: 25411425 Abstract Following injury, platelets rapidly interact with the exposed extracellular matrix (ECM) of the vessel wall and the surrounding tissues. Hyaluronan (HA) … Continued

Analysis of the heavy-chain modification and TSG-6 activity in pathological hyaluronan matrices

Lauer ME, Loftis J, de la Motte C, Hascall VC. Methods Mol Biol. 2015;1229:543-8. doi: 10.1007/978-1-4939-1714-3_42. PMID: 25325979 Abstract During inflammation and developmental processes, heavy chains (HCs) from inter-α-inhibitor (IαI) are covalently transferred to hyaluronan (HA) via the enzyme tumor-necrosis-factor-stimulated-gene 6 (TSG-6) … Continued

A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web regression

Dubail J, Aramaki-Hattori N, Bader HL, Nelson CM, Katebi N, Matuska B, Olsen BR, Apte SS. Genesis. 2014 Jul;52(7):702-12. doi: 10.1002/dvg.22784. PMID: 24753090 Abstract ADAMTS9 is the most conserved member of a large family of secreted metalloproteases having diverse functions. Adamts9 null … Continued

Breathprints of childhood obesity: changes in volatile organic compounds in obese children compared with lean controls

Alkhouri N, Eng K, Cikach F, Patel N, Yan C, Brindle A, Rome E, Hanouneh I, Grove D, Lopez R, Hazen SL, Dweik RA. Pediatr Obes. 2015 Feb;10(1):23-9. doi: 10.1111/j.2047-6310.2014.221.x. PMID: 24677760 Abstract OBJECTIVE: The objective of this study was to investigate … Continued

Subcutaneous to intravenous prostacyclin analog transition in pulmonary hypertension

Alkukhun L, Bair ND, Dweik RA, Tonelli AR. J Cardiovasc Pharmacol. 2014 Jan;63(1):4-8. doi: 10.1097/FJC.0000000000000018. PMID: 24084219 Abstract INTRODUCTION: Prostacyclin analogs are Food and Drug Administration-approved therapies for the treatment of pulmonary arterial hypertension and can be administered by inhalational, intravenous (IV), … Continued

Project 5 Update

AIM 1: We are revising a manuscript (for Cell Reports) that shows how ADAMTS9 regulates the growth of arteries. Specifically, we show, using a new gene-trap mouse allele, that ADAMTS9 is essential for matrix remodeling in the umbilical cord that … Continued

The multiple, complex roles of versican and its proteolytic turnover by ADAMTS proteases during embryogenesis

Nandadasa S, Foulcer S, Apte SS. The multiple, complex roles of versican and its proteolytic turnover by ADAMTS proteases during embryogenesis. Matrix Biol. 2014 Apr;35:34-41. doi: 10.1016/j.matbio.2014.01.005. PMID: 24444773 Abstract Embryonic development is an exceptionally dynamic process, requiring a provisional … Continued

Isolation and purification of versican and analysis of versican proteolysis

Foulcer SJ, Day AJ, Apte SS. Isolation and purification of versican and analysis of versican proteolysis. Methods Mol Biol. 2015;1229:587-604. doi: 10.1007/978-1-4939-1714-3_46. PMID: 25325983 Abstract Versican is a widely distributed chondroitin sulfate proteoglycan that forms large complexes with the glycosaminoglycan … Continued

Is pulmonary hypertension a metabolic disease?

Barnes J, Dweik RA. Is pulmonary hypertension a metabolic disease? Am J Respir Crit Care Med. 2014 Nov 1;190(9):973-5. doi: 10.1164/rccm.201409-1702ED. PMID: 25360726 PMCID: PMC4299590

Volatile organic compounds in bile can diagnose malignant biliary strictures in the setting of pancreatic cancer: a preliminary observation

Navaneethan U, Parsi MA, Gutierrez NG, Bhatt A, Venkatesh PG, Lourdusamy D, Grove D, Hammel JP, Jang S, Sanaka MR, Stevens T, Vargo JJ,Dweik RA. Volatile organic compounds in bile can diagnose malignant biliary strictures in the setting of pancreatic cancer: a preliminary observation. Gastrointest Endosc. 2014 Dec;80(6):1038-45. doi: 10.1016/j.gie.2014.04.016. PMID: … Continued

Leptin deficiency recapitulates the histological features of pulmonary arterial hypertension in mice

Aytekin M, Tonelli AR, Farver CF, Feldstein AE, Dweik RA. Leptin deficiency recapitulates the histological features of pulmonary arterial hypertension in mice. Int J Clin Exp Pathol. 2014 Apr 15;7(5):1935-46. PMID: 24966903 PMCID: PMC4069962 Abstract Leptin is a neuroendocrine peptide … Continued

The dietary polysaccharide maltodextrin promotes Salmonella survival and mucosal colonization in mice

Nickerson KP, Homer CR, Kessler SP, Dixon LJ, Kabi A, Gordon IO, Johnson EE, de la Motte CA, McDonald C. The dietary polysaccharide maltodextrin promotes Salmonella survival and mucosal colonization in mice. PLoS One. 2014 Jul 7;9(7):e101789. doi: 10.1371/journal.pone.0101789. PMID: 25000398 PMCID: PMC4084946 Abstract In the latter half … Continued

Compartmentalization and Kinetics of Counterbalancing Signals in Cardiac Transplants

Kaul A, Goparaju S, Dvorina N, Iida S, Keslar K, de la Motte C, Valujskik A, Fairchild R and Baldwin W. Acute and Chronic Rejection: Compartmentalization and Kinetics of Counterbalancing Signals in Cardiac Transplants. Am J Transplant. 15:333-45 (2015) PMID: … Continued

Roles of proteoglycans and glycosaminoglycans in wound healing and fibrosis

Ghatak S, Markwald RR, Hascall VC, Maytin EV, Mack JA, Atanelishvili I, Rodriguez RM, Misra S. Roles of proteoglycans and glycosaminoglycans in wound healing and fibrosis. Int J Cell Biol (2015 accepted).

Isothiocyanate analogs targeting CD44 receptor as an effective strategy against colon cancer

Misra S, Ghatak S, Vyas A, O’Brien P, Markwald RR, Khetmalas M, Hascall VC, McCarthy JB, Karamanos NK, Tammi MI, Tammi RH, Prestwitch GD, Padhye S. Isothiocyanate analogs targeting CD44 receptor as an effective strategy against colon cancer. Med Chem … Continued

Natural antisense transcript for hyaluronan synthase 2 (HAS2-AS1) induces transcription of HAS2 via protein O-GlcNAcylation

Vigetti D, Deleonibus S, Moretto P, Bowen T, Fischer JW, Grandoch M, Oberhuber A, Love DC, Hanover JA, Cinquetti R, Karousou E, Viola M, D’Angelo ML, Hascall VC, De Luca G, Passi A. Natural antisense transcript for hyaluronan synthase 2 … Continued

Analysis of the heavy-chain modification and TSG-6 activity in pathological hyaluronan matrices

Lauer ME, Loftis J, de la Motte C, Hascall VC. Analysis of the heavy-chain modification and TSG-6 activity in pathological hyaluronan matrices. Methods Mol Biol. 2015;1229:543-8. doi: 10.1007/978-1-4939-1714-3_42. PMID: 25325979 PMCID: PMC4397960 Abstract During inflammation and developmental processes, heavy chains … Continued

Heavy chain transfer by tumor necrosis factor-stimulated gene 6 to the bikunin proteoglycan

Lamkin E, Cheng G, Calabro A, Hascall VC, Joo EJ, Li L, Linhardt RJ, Lauer ME. Heavy chain transfer by tumor necrosis factor-stimulated gene 6 to the bikunin proteoglycan. J Biol Chem. 2015 Feb 20;290(8):5156-66. doi: 10.1074/jbc.M114.636258. PMID: 25561734 PMCID: … Continued

Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer

Misra S, Hascall VC, Markwald RR, Ghatak S. Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer. Front Immunol. 2015 May 6;6:201. doi: 10.3389/fimmu.2015.00201. PMID: 25999946 PMCID: PMC4422082 Abstract The glycosaminoglycan hyaluronan (HA), a … Continued

Heparin interaction with a receptor on hyperglycemic dividing cells prevents intracellular hyaluronan synthesisand autophagy responses in models of type 1 diabetes

Wang A, Sankaranarayanan NV, Yanagishita M, Templeton DM, Desai UR, Sugahara K, Wang CP, Hascall VC. Heparin interaction with a receptor on hyperglycemic dividing cells prevents intracellular hyaluronan synthesisand autophagy responses in models of type 1 diabetes. Matrix Biol. 2015 … Continued

Hyaluronan regulates bone morphogenetic protein-7-dependent prevention and reversal of myofibroblast phenotype

Midgley AC, Duggal L, Jenkins R, Hascall V, Steadman R, Phillips AO, Meran S. Hyaluronan regulates bone morphogenetic protein-7-dependent prevention and reversal of myofibroblast phenotype. J Biol Chem. 2015 May 1;290(18):11218-34. doi: 10.1074/jbc.M114.625939. PMID: 25716319 PMCID: PMC4416830 Abstract Hyaluronan (HA) … Continued

Utilization of GAGs/PGs as carriers for targeted therapy delivery

Misra S, Hascall V, Markwald R, Atanelishvili I, Moreno-Rodriguez, R, Ghatak S. Utilization of GAGs/PGs as carriers for targeted therapy delivery. Int. J. Cell Biol. 2015 (In Press)

Hyaluronan synthase 2 protects skin fibroblasts against apoptosis induced by environmental stress.

Wang Y, Lauer ME, Anand S, Mack JA, Maytin EV. (2014) Hyaluronan synthase 2 protects skin fibroblasts against apoptosis induced by environmental stress. J Biol Chem. 289(46):32253-65. PMID: 25266724. PMCID: PMC4231699. Abstract A balanced turnover of dermal fibroblasts is crucial … Continued

Irreversible heavy chain transfer to chondroitin

Lauer ME, Hascall VC, Green DE, DeAngelis PL, Calabro A. (2014) Irreversible heavy chain transfer to chondroitin. J Biol Chem. 289(42):29171-9. PMID: 25135638. PMCID:PMC4200270. Abstract We have recently demonstrated that the transfer of heavy chains (HCs) from inter-α-inhibitor, via the … Continued

Why patients who die of worsening pulmonary arterial hypertension are not on parenteral prostacyclin analog treatment?

Tonelli AR, Dweik RA. (2014) Why patients who die of worsening pulmonary arterial hypertension are not on parenteral prostacyclin analog treatment? J Heart Lung Transplant. 33(2):221. PMID: 24157181. PMCID: PMC4126496. Link to journal: http://www.jhltonline.org/

Determinants of versican-V1 proteoglycan processing by the metalloproteinase ADAMTS5

Foulcer SJ, Nelson CM, Quintero MV, Kuberan B, Larkin J, Dours-Zimmermann MT, Zimmermann DR, Apte SS. (2014) Determinants of versican-V1 proteoglycan processing by the metalloproteinase ADAMTS5. J Biol Chem. 289(40):27859-73. PMID: 25122765. PMCID: PMC4183820. Abstract Proteolysis of the Glu(441)-Ala(442) bond … Continued

Umbilical cord mesenchymal stem cells suppress host rejection: the role of the glycocalyx

Coulson-Thomas VJ, Gesteira TF, Hascall V, Kao W. (2014) Umbilical cord mesenchymal stem cells suppress host rejection: the role of the glycocalyx. J Biol Chem. 289(34):23465-81. PMID: 24986866. PMCID: PMC4156039. Abstract Umbilical cord mesenchymal stem cells (UMSCs) have unique immunosuppressive … Continued

Metabolomic analysis of breath volatile organic compounds reveals unique breathprints in children with inflammatory bowel disease: a pilot study.

Patel N, Alkhouri N, Eng K, Cikach F, Mahajan L, Yan C, Grove D, Rome ES, Lopez R, Dweik RA. (2014) Metabolomic analysis of breath volatile organic compounds reveals unique breathprints in children with inflammatory bowel disease: a pilot study. … Continued

A novel method for pulmonary research: Assessment of bioenergetic function at the air-liquid interface.

Xu W, Janocha AJ, Leahy RA, Klatte R, Dudzinski D, Mavrakis LA, Comhair SA, Lauer ME, Cotton CU, Erzurum SC. (2014) A novel method for pulmonary research: Assessment of bioenergetic function at the air-liquid interface. Redox Biol. 2:513-9. PMID: 24624341; PMCID: PMC3949089 Abstract Air-liquid interface … Continued

Hyperglycemia diverts dividing osteoblastic precursor cells to an adipogenic pathway and induces synthesis of a hyaluronan matrix that is adhesive for monocytes.

Wang A, Midura RJ, Vasanji A, Wang AJ, Hascall VC. (2014) Hyperglycemia diverts dividing osteoblastic precursor cells to an adipogenic pathway and induces synthesis of a hyaluronan matrix that is adhesive for monocytes. J Biol Chem. 289(16):11410-20. PMID: 24569987; PMCID: PMC4036277 Abstract Isolated rat bone marrow … Continued

Periostin induces intracellular cross-talk between kinases and hyaluronan in atrioventricular valvulogenesis.

Ghatak S, Misra S, Norris RA, Moreno-Rodriguez RA, Hoffman S, Levine RA, Hascall VC, Markwald RR. (2014) Periostin induces intracellular cross-talk between kinases and hyaluronan in atrioventricular valvulogenesis. J Biol Chem. 289(12):8545-61. PMID: 24469446; PMCID: PMC3961678 Abstract Periostin (PN), a novel fasciclin-related matricellular protein, has been implicated in cardiac development and postnatal remodeling, … Continued

Heparin prevents intracellular hyaluronan synthesis and autophagy responses in hyperglycemic dividing mesangial cells and activates synthesis of an extensive extracellular monocyte-adhesive hyaluronan matrix after completing cell division.

Wang A1, Ren J, Wang CP, Hascall VC. (2014) Heparin prevents intracellular hyaluronan synthesis and autophagy responses in hyperglycemic dividing mesangial cells and activates synthesis of an extensive extracellular monocyte-adhesive hyaluronan matrix after completing cell division. J Biol Chem. 289(13):9418-29. PMID: 24482224; PMCID: PMC3979390   Abstract Growth-arrested rat mesangial … Continued

Overexpression of c-Met and CD44v6 receptors contributes to autocrine TGF-β1 signaling in interstitial lung disease.

Ghatak S, Bogatkevich GS, Atnelishvili I, Akter T, Feghali-Bostwick C, Hoffman S, Fresco VM, Fuchs JC, Visconti RP, Markwald RR, Padhye SB, Silver RM,Hascall VC, Misra S. (2014) Overexpression of c-Met and CD44v6 receptors contributes to autocrine TGF-β1 signaling in interstitial lung disease. J Biol Chem. 289(11):7856-72. PMID: 24324260; PMCID: PMC3953297   Abstract The hepatocyte growth factor (HGF) … Continued

Sublingual microcirculation in pulmonary arterial hypertension

Dababneh L, Cikach F, Alkukhun L, Dweik RA, Tonelli AR.(2014) Sublingual microcirculation in pulmonary arterial hypertension. Ann Am Thorac Soc. 11(4):504-12. PMID: 24601682. PMCID: PMC4225801. Abstract RATIONALE:  Pulmonary arterial hypertension (PAH) is a pulmonary vasculopathy that leads to failure of … Continued

Presence and outcomes of kidney disease in patients with pulmonary hypertension.

Navaneethan SD, Wehbe E, Heresi GA, Gaur V, Minai OA, Arrigain S, Nally JV Jr, Schold JD, Rahman M, Dweik RA. (2014) Presence and outcomes of kidney disease in patients with pulmonary hypertension. Clin J Am Soc Nephrol. 9(5):855-63. PMID: … Continued

Breath analysis in pulmonary arterial hypertension.

Cikach FS Jr, Tonelli AR, Barnes J, Paschke K, Newman J, Grove D, Dababneh L, Wang S, Dweik RA. (2014) Breath analysis in pulmonary arterial hypertension. Chest. 145(3):551-8. PMID: 24091389; PMCID: PMC3941248   Abstract BACKGROUND: Pulmonary arterial hypertension (PAH) is a progressive and devastating condition characterized by vascular cell proliferation and is associated with … Continued

A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web regression.

Dubail J, Aramaki-Hattori N, Bader HL, Nelson CM, Katebi N, Matuska B, Olsen BR, Apte SS. (2014) A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web regression. Genesis. 2014 Apr 20. doi: 10.1002/dvg.22784. PMID: 24753090. Abstract … Continued

Hyperglycemia diverts dividing osteoblastic precursor cells to an adipogenic pathway and induces synthesis of a hyaluronan matrix that is adhesive for monocytes.

Wang A, Midura RJ, Vasanji A, Wang AJ, Hascall VC. (2014) Hyperglycemia diverts dividing osteoblastic precursor cells to an adipogenic pathway and induces synthesis of a hyaluronan matrix that is adhesive for monocytes. J Biol Chem. 289(16):11410-20. PMID: 24569987. Abstract: … Continued

The dynamic metabolism of hyaluronan regulates the cytosolic concentration of UDP-GlcNAc.

Hascall VC, Wang A, Tammi M, Oikari S, Tammi R, Passi A, Vigetti D, Hanson RW, Hart GW. (2014) The dynamic metabolism of hyaluronan regulates the cytosolic concentration of UDP-GlcNAc. Matrix Biol. 35:14-7. PMID: 24486448. PMCID: PMC4039572. Abstract Hyaluronan, a … Continued

The multiple, complex roles of versican and its proteolytic turnover by ADAMTS proteases during embryogenesis.

Nandadasa S, Foulcer S, Apte SS. (2014) The multiple, complex roles of versican and its proteolytic turnover by ADAMTS proteases during embryogenesis. Matrix Biol. 35:34-41. PMID: 2444473. Abstract Embryonic development is an exceptionally dynamic process, requiring a provisional extracellular matrix … Continued

The Breathprints in Patients With Liver Disease Identify Novel Breath Biomarkers in Alcoholic Hepatitis.

Hanouneh IA, Zein NN, Cikach F, Dababneh L, Grove D, Alkhouri N, Lopez R, Dweik RA. (2014) The Breathprints in Patients With Liver Disease Identify Novel Breath Biomarkers in Alcoholic Hepatitis. Clin Gastroenterol Hepatol. 12(3):516-23. PMID: 24036050. PMCID: PMC3971429. Abstract … Continued

Hyaluronan, a crucial regulator of inflammation.

Petrey AC, de la Motte CA. (2014) Hyaluronan, a crucial regulator of inflammation. Front Immunol.5:101. PMID: 24653726. PMCID: PMC3949149. Abstract Hyaluronan (HA), a major component of the extracellular matrix (ECM), plays a key role in regulating inflammation. Inflammation is associated … Continued

Modification of hyaluronan by heavy chains of inter-α-inhibitor in idiopathic pulmonary arterial hypertension.

Lauer ME, Aytekin M, Comhair SA, Loftis J, Tian L, Farver CF, Hascall VC, Dweik RA. (2014) Modification of hyaluronan by heavy chains of inter-α-inhibitor in idiopathic pulmonary arterial hypertension. J Biol Chem. 289(10):6791-8. PMID: 24403074. PMCID: PMC3945340. Abstract We … Continued

Long-term continuous positive airway pressure therapy normalizes high exhaled nitric oxide levels in obstructive sleep apnea.

Chua AP, Aboussouan LS, Minai OA, Paschke K, Laskowski D, Dweik RA. (2013) Long-term continuous positive airway pressure therapy normalizes high exhaled nitric oxide levels in obstructive sleep apnea. J Clin Sleep Med. 9(6):529-35. PMID: 23772184; PMCID: PMC3659371   Abstract STUDY OBJECTIVES: Upper airway inflammation and oxidative stress … Continued

Time-resolved analysis of the matrix metalloproteinase 10 substrate degradome.

Schlage P, Egli FE, Nanni P, Wang LW, Kizhakkedathu JN, Apte SS, auf dem Keller U. (2014) Time-resolved analysis of the matrix metalloproteinase 10 substrate degradome. Mol Cell Proteomics. 13:580-93. PMID: 24281761. PMCID: PMC3916655. Abstract Proteolysis is an irreversible post-translational … Continued

Analysis of breath volatile organic compounds as a noninvasive tool to diagnose nonalcoholic fatty liver disease in children.

Alkhouri N, Cikach F, Eng K, Moses J, Patel N, Yan C, Hanouneh I, Grove D, Lopez R, Dweik R. (2014) Analysis of breath volatile organic compounds as a noninvasive tool to diagnose nonalcoholic fatty liver disease in children. Eur … Continued

Clinical characterization and survival of patients with borderline elevation in pulmonary artery pressure.

Heresi GA, Minai OA, Tonelli AR, Hammel JP, Farha S, Parambil JG, Dweik RA. (2013) Clinical characterization and survival of patients with borderline elevation in pulmonary artery pressure. Pulm Circ. 3(4):916-25. PMID: 25006408. PMCID: PMC4070822. Abstract Normal resting mean pulmonary … Continued

Molecular mass dependence of hyaluronan detection by sandwich ELISA-like assay and membrane blotting using biotinylated hyaluronan binding protein.

Yuan H, Tank M, Alsofyani A, Shah N, Talati N, LoBello JC, Kim JR, Oonuki Y, de la Motte CA, Cowman MK. (2013) Molecular mass dependence of hyaluronan detection by sandwich ELISA-like assay and membrane blotting using biotinylated hyaluronan binding … Continued

Causes and circumstances of death in pulmonary arterial hypertension.

Tonelli AR, Arelli V, Minai OA, Newman J, Bair N, Heresi GA, Dweik RA. (2013) Causes and circumstances of death in pulmonary arterial hypertension. Am J Respir Crit Care Med. 188(3):365-9. PMID: 23600433; PMCID: PMC3778730   Abstract RATIONALE: The causes and circumstances surrounding death are understudied in patients with pulmonary arterial hypertension … Continued

Human milk hyaluronan enhances innate defense of the intestinal epithelium.

Hill DR, Rho HK, Kessler SP, Amin R, Homer CR, McDonald C, Cowman MK, de la Motte CA. (2013) Human milk hyaluronan enhances innate defense of the intestinal epithelium. J Biol Chem. 288(40):29090-104. PMID: 23950179. PMCID: PMC3790008. Abstract Breast-feeding is … Continued

Polysomnographic determinants of nocturnal hypercapnia in patients with sleep apnea.

Jaimchariyatam N, Dweik RA, Kaw R, Aboussouan LS. (2013) Polysomnographic determinants of nocturnal hypercapnia in patients with sleep apnea. J Clin Sleep Med. 15;9(3):209-15. PMID: 23493528; PMCID: PMC3578680 Abstract STUDY OBJECTIVES: Identify polysomnographic and demographic factors associated with elevation of nocturnal end-tidal CO2 in patients with obstructive sleep apnea. … Continued

Overcoming neurite-inhibitory chondroitin sulfate proteoglycans in the astrocyte matrix.

Cua RC, Lau LW, Keough MB, Midha R, Apte SS, Yong VW. (2013) Overcoming neurite-inhibitory chondroitin sulfate proteoglycans in the astrocyte matrix. Glia.61(6):972-84. PMID: 23554135. Abstract Acute trauma to the central nervous system (CNS) can result in permanent damage and … Continued

The biology of the extracellular matrix: novel insights.

Hubmacher D, Apte SS. (2013) The biology of the extracellular matrix: novel insights. Curr Opin Rheumatol. 25(1):65-70. PMID: 23143224. PMCID: PMC3560377.   Abstract PURPOSE OF REVIEW: Extracellular matrix (ECM) has both structural and regulatory roles. This update reviews the representative recent developments in diverse … Continued

Versican processing by a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats proteinases-5 and -15 facilitates myoblast fusion.

Stupka N, Kintakas C, White JD, Fraser FW, Hanciu M, Aramaki-Hattori N, Martin S, Coles C, Collier F, Ward AC, Apte SS, McCulloch DR. (2013) Versican processing by a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats proteinases-5 and -15 facilitates myoblast fusion. J Biol Chem. 288(3):1907-17. PMID: 23233679; PMCID: PMC3548499   Abstract Skeletal muscle development and regeneration … Continued

Response.

Tonelli AR, Dweik RA. (2013) Response. Chest. 143(1):273-4. PMID: 23276860; PMCID: PMC3610693 Comment on Prevalence and prognostic value of left ventricular diastolic dysfunction in idiopathic and heritable pulmonary arterial hypertension. [Chest. 2012] Diastolic dysfunction with nondilated left atrium. [Chest. 2013] Link to journal: http://journal.publications.chestnet.org/

Single exhaled breath metabolomic analysis identifies unique breathprint in patients with acute decompensated heart failure.

Samara MA, Tang WH, Cikach F Jr, Gul Z, Tranchito L, Paschke KM, Viterna J, Wu Y, Laskowski D, Dweik RA. (2013) Single exhaled breath metabolomic analysis identifies unique breathprint in patients with acute decompensated heart failure. J Am Coll Cardiol. 61(13):1463-4. PMID: 23500243; PMCID: PMC3760473    No Abstract Available Link to journal: http://content.onlinejacc.org/journal.aspx

Irreversible heavy chain transfer to hyaluronan oligosaccharides by tumor necrosis factor-stimulated gene-6.

Lauer ME, Glant TT, Mikecz K, DeAngelis PL, Haller FM, Husni ME, Hascall VC, Calabro A. (2013) Irreversible heavy chain transfer to hyaluronan oligosaccharides by tumor necrosis factor-stimulated gene-6. J Biol Chem. 288(1):205-14. PMID: 23166324. PMCID: PMC3537015   Abstract The covalent transfer of heavy … Continued

Tumor necrosis factor-stimulated gene-6 (TSG-6) amplifies hyaluronan synthesis by airway smooth muscle cells.

Lauer ME, Cheng G, Swaidani S, Aronica MA, Weigel PH, Hascall VC. (2013) Tumor necrosis factor-stimulated gene-6 (TSG-6) amplifies hyaluronan synthesis by airway smooth muscle cells. J Biol Chem. 288(1):423-31. PMID: 23129777. PMCID: PMC3537040   Abstract We tested the hypothesis that the artificial addition of heavy … Continued

The biology of the extracellular matrix: novel insights.

Hubmacher D, Apte SS. (2013)  The biology of the extracellular matrix: novel insights. Curr Opin Rheumatol. 25(1):65-70. PMID: 23143224; PMCID: PMC3560377 Abstract PURPOSE OF REVIEW: Extracellular matrix (ECM) has both structural and regulatory roles. This update reviews the representative recent developments in diverse aspects of ECM biology relevant … Continued

Nitric oxide deficiency in pulmonary hypertension: Pathobiology and implications for therapy.

Tonelli AR, Haserodt S, Aytekin M, Dweik RA. (2013) Nitric oxide deficiency in pulmonary hypertension: Pathobiology and implications for therapy. Pulm Circ. 3(1):20-30. PMID: 23662172. PMCID: PMC3641730. Abstract Nitric oxide (NO) is a diffusible gas with diverse roles in human … Continued

Correlation of hyaluronan deposition with infiltration of eosinophils and lymphocytes in a cockroach-induced murine model of asthma.

Cheng G, Swaidani S, Sharma M, Lauer ME, Hascall VC, Aronica MA. (2013) Correlation of hyaluronan deposition with infiltration of eosinophils and lymphocytes in a cockroach-induced murine model of asthma. Glycobiology. 23(1):43-58. PMID: 22917573. PMCID: PMC3505010. Abstract Asthma is a … Continued

TSG-6 protein is crucial for the development of pulmonary hyaluronan deposition, eosinophilia, and airway hyperresponsiveness in a murine model of asthma.

Swaidani S, Cheng G, Lauer ME, Sharma M, Mikecz K, Hascall VC, Aronica MA. (2013) TSG-6 protein is crucial for the development of pulmonary hyaluronan deposition, eosinophilia, and airway hyperresponsiveness in a murine model of asthma. J Biol Chem. 288(1):412-22. … Continued

Cardiovascular biomarkers in exhaled breath.

Cikach FS Jr, Dweik RA. (2012) Cardiovascular biomarkers in exhaled breath. Prog Cardiovasc Dis. 55(1):34-43. PMID: 22824108. Abstract With each breath that we exhale, thousands of molecules are expelled in our breath, giving individuals a “breath-print” that can tell a lot … Continued

Prevalence and prognostic value of left ventricular diastolic dysfunction in idiopathic and heritable pulmonary arterial hypertension.

Tonelli AR, Plana JC, Heresi GA, Dweik RA. (2012) Prevalence and prognostic value of left ventricular diastolic dysfunction in idiopathic and heritable pulmonary arterial hypertension. Chest. 141(6):1457-65. PMID: 2220768. PMCID: PMC3367485   Abstract BACKGROUND: Little is known about the association between left ventricular (LV) … Continued

Nitric oxide and asthma severity: towards a better understanding of asthma phenotypes.

Aytekin M, Dweik RA. (2012) Nitric oxide and asthma severity: towards a better understanding of asthma phenotypes. Clin Exp Allergy. 42(5):614-6. doi: 10.1111/j.1365-2222.2012.03976.x. PMID: 22515385; PMCID: PMC3335741.

Portopulmonary hypertension: a report from the US-based REVEAL Registry.

Krowka MJ, Miller DP, Barst RJ, Taichman D, Dweik RA, Badesch DB, McGoon MD. (2012) Portopulmonary hypertension: a report from the US-based REVEAL Registry. Chest. 141(4):906-15. PMID: 21778257   Abstract BACKGROUND: We evaluated survival and hospitalization rates in patients with group 1 portopulmonary hypertension (PoPH) in the … Continued

Sensitive cardiac troponin I predicts poor outcomes in pulmonary arterial hypertension.

Heresi GA, Tang WH, Aytekin M, Hammel J, Hazen SL, Dweik RA. (2012) Sensitive cardiac troponin I predicts poor outcomes in pulmonary arterial hypertension. Eur Respir J. 39(4):939-44. PMID: 21885398   Abstract Circulating cardiac troponins are markers of myocardial injury. We sought to determine whether cardiac troponin … Continued

Abnormal platelet aggregation in idiopathic pulmonary arterial hypertension: role of nitric oxide.

Aytekin M, Aulak KS, Haserodt S, Chakravarti R, Cody J, Minai OA, Dweik RA. (2012) Abnormal platelet aggregation in idiopathic pulmonary arterial hypertension: role of nitric oxide. Am J Physiol Lung Cell Mol Physiol. 302(6):L512-20. PMID: 22246002; PMCID: PMC3311529. Abstract Idiopathic … Continued

Heart rate recovery predicts clinical worsening in patients with pulmonary arterial hypertension.

Minai OA, Gudavalli R, Mummadi S, Liu X, McCarthy K, Dweik RA. (2012) Heart rate recovery predicts clinical worsening in patients with pulmonary arterial hypertension. Am J Respir Crit Care Med. 185(4):400-8. PMID: 22108205   Abstract RATIONALE: Reduced heart rate recovery … Continued

ADAMTSL4, a secreted glycoprotein widely distributed in the eye, binds fibrillin-1 microfibrils and accelerates microfibril biogenesis.

Gabriel LA, Wang LW, Bader H, Ho JC, Majors AK, Hollyfield JG, Traboulsi EI, Apte SS. (2012) ADAMTSL4, a secreted glycoprotein widely distributed in the eye, binds fibrillin-1 microfibrils and accelerates microfibril biogenesis. Invest Ophthalmol Vis Sci. 53(1):461-9. PMID: 21989719; PMCID: … Continued

Enhanced inflammation and accelerated wound closure following tetraphorbol ester application or full-thickness wounding in mice lacking hyaluronan synthases Has1 and Has3.

Mack JA, Feldman RJ, Itano N, Kimata K, Lauer M, Hascall VC, Maytin EV. (2012) Enhanced inflammation and accelerated wound closure following tetraphorbol ester application or full-thickness wounding in mice lacking hyaluronan synthases Has1 and Has3. J Invest Dermatol. 132(1):198-207. … Continued

An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications.

Dweik RA, Boggs PB, Erzurum SC, Irvin CG, Leigh MW, Lundberg JO, Olin AC, Plummer AL, Taylor DR; American Thoracic Society Committee on Interpretation of Exhaled Nitric Oxide Levels (FENO) for Clinical Applications. (2011) An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am … Continued

Pericellular versican regulates the fibroblast-myofibroblast transition: a role for ADAMTS5 protease-mediated proteolysis.

Hattori N, Carrino DA, Lauer ME, Vasanji A, Wylie JD, Nelson CM, Apte SS. (2011) Pericellular versican regulates the fibroblast-myofibroblast transition: a role for ADAMTS5 protease-mediated proteolysis. J Biol Chem. 286(39):34298-310. PMID: 21828051; PMCID: PMC3190794. Abstract The cell and its glycosaminoglycan-rich … Continued

The great challenge for exhaled breath analysis: embracing complexity, delivering simplicity.

Dweik RA. (2011) The great challenge for exhaled breath analysis: embracing complexity, delivering simplicity. J Breath Res. 5(3):030201.  PMID: 21900732. Link to journal: http://iopscience.iop.org/1752-7163/

Role of receptor for hyaluronic acid-mediated motility (RHAMM) in low molecular weight hyaluronan (LMWHA)-mediated fibrosarcoma cell adhesion.

Kouvidi K, Berdiaki A, Nikitovic D, Katonis P, Afratis N, Hascall VC, Karamanos NK, Tzanakakis GN. (2011) Role of receptor for hyaluronic acid-mediated motility (RHAMM) in low molecular weight hyaluronan (LMWHA)-mediated fibrosarcoma cell adhesion. J Biol Chem. 286:38509-20. PMID: 21914806. … Continued

The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation.

Bulek K, Liu C, Swaidani S, Wang L, Page RC, Gulen MF, Herjan T, Abbadi A, Qian W, Sun D, Lauer M, Hascall V, Misra S, Chance MR, Aronica M, Hamilton T, Li X. (2011) The inducible kinase IKKi is … Continued

Glycosaminoglycans and glucose prevent apoptosis in 4-methylumbelliferone-treated human aortic smooth muscle cells.

Vigetti D, Rizzi M, Moretto P, Deleonibus S, Dreyfuss JM, Karousou E, Viola M, Clerici M, Hascall VC, Ramoni MF, De Luca G, Passi A. (2011) Glycosaminoglycans and glucose prevent apoptosis in 4-methylumbelliferone-treated human aortic smooth muscle cells. J Biol … Continued

Strengths and limitations of the six-minute-walk test: a model biomarker study in idiopathic pulmonary fibrosis.

Heresi GA, Dweik RA. (2011) Strengths and limitations of the six-minute-walk test: a model biomarker study in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 183(9):1122-4. PMID: 21531951 Link to journal: http://www.atsjournals.org/journal/ajrccm