Nitric oxide deficiency in pulmonary hypertension: Pathobiology and implications for therapy.

Tonelli AR, Haserodt S, Aytekin M, Dweik RA. (2013) Nitric oxide deficiency in pulmonary hypertension: Pathobiology and implications for therapy. Pulm Circ. 3(1):20-30. PMID: 23662172. PMCID: PMC3641730.

Abstract

Nitric oxide (NO) is a diffusible gas with diverse roles in human physiology and disease. Significant progress in the understanding of its biological effects has taken place in recent years. This has led to a better understanding of the pathobiology of pulmonary hypertension (PH) and the development of new therapies. This article provides an overview of the NO physiology and its role in the pathobiology of lung diseases, particularly PH. We also discuss current and emerging specific treatments that target NO signaling pathways in PH.

Keywords

nitric oxide; physiopathology and therapeutics; pulmonary hypertension

Link to journal: http://www.press.uchicago.edu/ucp/journals/journal/pc.html