Hyaluronidase and Hyaluronan Oligosaccharides Promote Neurological Recovery after Intraventricular Hemorrhage

Vinukonda G, Dohare P, Arshad A, Zia MT, Panda S, Korumilli R, Kayton R, Hascall VC, Lauer ME, Ballabh P. J Neurosci. 2016 Jan 20;36(3):872-89. doi: 10.1523/JNEUROSCI.3297-15.2016. PMID: 26791217 Abstract Intraventricular hemorrhage (IVH) in premature infants results in inflammation, arrested oligodendrocyte progenitor … Continued

Anti-ADAMTS5 monoclonal antibodies: implications for aggrecanase inhibition in osteoarthritis

Apte SS. Biochem J. 2016 Jan 1;473(1):e1-4. doi: 10.1042/BJ20151072. Review. PMID: 26657033 Abstract The extracellular matrix of articular cartilage is structurally specialized for efficient absorption of mechanical impact. In particular, giant aggregates of the large chondroitin sulfate proteoglycan, aggrecan, with the glycosaminoglycan, … Continued

Hyaluronan Rafts on Airway Epithelial Cells

Abbadi A, Lauer M, Swaidani S, Wang A, Hascall V. J Biol Chem. 2016 Jan 15;291(3):1448-55. doi: 10.1074/jbc.M115.704288. PMID: 26601955 Abstract Many cells, including murine airway epithelial cells, respond to a variety of inflammatory stimuli by synthesizing leukocyte-adhesive hyaluronan (HA) cables that … Continued

Hyaluronan’s Role in Fibrosis: A Pathogenic Factor or a Passive Player?

Albeiroti S, Soroosh A, de la Motte CA. Biomed Res Int. 2015;2015:790203. doi: 10.1155/2015/790203. Review. PMID: 26583132 Abstract Fibrosis is a debilitating condition that can lead to impairment of the affected organ’s function. Excessive deposition of extracellular matrix (ECM) molecules is characteristic … Continued

Hyaluronan Synthase 3 Null Mice Exhibit Decreased Intestinal Inflammation and Tissue Damage in the DSS-Induced Colitis Model

Kessler SP, Obery DR, de la Motte C. Int J Cell Biol. 2015;2015:745237. doi: 10.1155/2015/745237. PMID: 26448758 Abstract Hyaluronan (HA) overproduction is a hallmark of multiple inflammatory diseases, including inflammatory bowel disease (IBD). Hyaluronan can act as a leukocyte recruitment molecule and … Continued

The Rise and Fall of Hyaluronan in Respiratory Diseases

Lauer ME, Dweik RA, Garantziotis S, Aronica MA. Int J Cell Biol. 2015;2015:712507. doi: 10.1155/2015/712507. Review. PMID: 26448757 Abstract In normal airways, hyaluronan (HA) matrices are primarily located within the airway submucosa, pulmonary vasculature walls, and, to a lesser extent, the alveoli. … Continued