Projects

Glycoconjugates & Cardiovascular Disease

The overall goals of this PEG are to elucidate the molecular roles of glycoconjugates in fundamental mechanisms that protect the heart from acute ischemic injury, in the short term, or that chronically lead to cardiomyopathies, myocardial infarction, ischemic injury and ultimately heart failure in the long term. The PEG is designed to work closely with local cardiologists to not only educate them about the importance of glycoconjugates to cardiovascular disease, and to reciprocally educate glycoscientists about cardiac physiology, but also to facilitate translation of our findings. By design our team will concomitantly investigate the roles of different classes of glycoconjugates. This team design was deliberate for two reasons: 1) The biological focus on mechanisms leading to myocardial infarction, ischemic injury and heart failure will engender broad ranging interactions, and interplay between the various projects and cores, since the roles of distinct glycoconjugates in cardiovascular disease occur at different places in the pathways involved. 2) A major goal of this PEG is to train the next generation of glycoscientists and to provide them with the knowledge and skills to perform glycoscience research at the highest level. This goal can only be met by having a cadre of outstanding glycoscientists on the team who each bring to the table cutting‐edge expertise on each of the types of glycoconjugates important to the research mission of NHLBI. Thus, our PEG is unique in that it not only addresses a key biomedical problem, but also does so in a fashion that will bring together an outstanding training environment for our Fellows and the community.

Link CardioPEG Webpage

Project 1: Crosstalk Between O-GlcNAcylation and Phosphorylation in Diabetic Cardiomyopathy

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Project 2: O-GlcNAcylation and Cardioprotection

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Project 3: Glycoprotein involvement in cardiac fibroblast-myocyte communication

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Project 4: Roles of Platelet Glycoproteins & Glycans on Platelet Reactivity & Cardiovascular Disease

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Project 5: Glycosphingolipids, Glycosyltransferases and Cardiovascular Disease

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