Harlan R, Zhang H. (2014) Targeted proteomics: a bridge between discovery and validation. Expert Rev Proteomics. 11(6):657-61. PMID: 25348939.
New technologies in mass spectrometry are beginning to mature and show unique advantages for the identification and quantitation of proteins. In recent years, one of the significant goals of clinical proteomics has been to identify biomarkers that can be used for clinical diagnosis. As technology has progressed, the list of potential biomarkers has grown. However, the verification and validation of these potential biomarkers is increasingly challenging and require high-throughput quantitative assays, targeting specific candidates. Targeted proteomics bridges the gap between biomarker discovery and the development of clinically applicable biomarker assays.
KEYWORDS: LC–MS; MRM; PRM; SRM; biomarker; proteomics; targeted proteomics
Link to journal: http://informahealthcare.com/journal/eru