Nutrient Regulation of Transcription, Signaling, and Cell Physiology by O-GlcNAcylation.

Stéphan Hardivillé and Gerald W. Hart (2014) Nutrient Regulation of Transcription, Signaling, and Cell Physiology by O-GlcNAcylation. Cell Metab. 20:208-213. PMID: 25100062.

Abstract

The nutrient sensor, O-linked N-acetylglucosamine (O-GlcNAc), cycles on and off nuclear and cytosolic proteins to regulate many cellular processes, including transcription and signaling. Dysregulated O-GlcNAcylation and its interplay with phosphorylation contribute to the etiology of diabetes, cancer, and neurodegeneration. Herein, we review recent findings about O-GlcNAc’s regulation of cell physiology.

Copyright © 2014 Elsevier Inc. All rights reserved.

Link to journal: http://www.cell.com/cell-metabolism/home

Link to copyright: http://www.elsevier.com/