Identification and Validation of Atypical N-Glycosylation Sites

Sun S, Zhang H. Anal Chem. 2015 Dec 15;87(24):11948-51. doi: 10.1021/acs.analchem.5b03886. PMID: 26593774 Abstract It is well-known that N-linked glycans usually attach to asparagine residues in the N-X-S/T motifs of proteins. However, accumulating evidence indicates that N-glycosylation could also possibly occur at … Continued

Transcriptional Landscape of Cardiomyocyte Maturation

Uosaki H, Cahan P, Lee DI, Wang S, Miyamoto M, Fernandez L, Kass DA, Kwon C. Cell Rep. 2015 Nov 24;13(8):1705-16. doi: 10.1016/j.celrep.2015.10.032. PMID: 26586429 Abstract Decades of progress in developmental cardiology has advanced our understanding of the early aspects of heart … Continued

O-GlcNAcomic Profiling Identifies Widespread O-Linked β-N-Acetylglucosamine Modification (O-GlcNAcylation) in Oxidative Phosphorylation System Regulating Cardiac Mitochondrial Function

Ma J, Liu T, Wei AC, Banerjee P, O’Rourke B, Hart GW. J Biol Chem. 2015 Dec 4;290(49):29141-53. doi: 10.1074/jbc.M115.691741. PMID: 26446791 Abstract Dynamic cycling of O-linked β-N-acetylglucosamine (O-GlcNAc) on nucleocytoplasmic proteins serves as a nutrient sensor to regulate numerous biological processes. … Continued

Elucidation of the CHO Super-Ome (CHO-SO) by Proteoinformatics

Kumar A, Baycin-Hizal D, Wolozny D, Pedersen LE, Lewis NE, Heffner K, Chaerkady R, Cole RN, Shiloach J, Zhang H, Bowen MA, Betenbaugh MJ. J Proteome Res. 2015 Nov 6;14(11):4687-703. doi: 10.1021/acs.jproteome.5b00588. PMID: 26418914 Abstract Chinese hamster ovary (CHO) cells are the … Continued

Identification and biological consequences of the O-GlcNAc modification of the human innate immune receptor, Nod2

Hou CW, Mohanan V, Zachara NE, Grimes CL. Glycobiology. 2016 Jan;26(1):13-8. doi: 10.1093/glycob/cwv076. PMID: 26369908 Abstract Nucleotide-binding oligomerization domain 2 (Nod2) is an intracellular receptor that can sense the bacterial peptidoglycan component, muramyl dipeptide. Upon activation, Nod2 induces the production of various … Continued