Molecular Functions of Glycoconjugates in Autophagy

Fahie K, Zachara NE. J Mol Biol. 2016 Aug 14;428(16):3305-24. doi: 10.1016/j.jmb.2016.06.011. Review. PMID: 2734566 Abstract Glycoconjugates, glycans, carbohydrates, and sugars: these terms encompass a class of biomolecules that are diverse in both form and function ranging from free oligosaccharides, glycoproteins, and … Continued

Nutrient regulation of gene expression by O-GlcNAcylation of chromatin

Hardivillé S, Hart GW. Curr Opin Chem Biol. 2016 Aug;33:88-94. doi: 10.1016/j.cbpa.2016.06.005. Review. PMID: 27322399 Abstract O-GlcNAcylation is a dynamic post-translational modification that is responsive to nutrient availably via the hexosamine biosynthetic pathway and its endproduct UDP-GlcNAc. O-GlcNAcylation serves as a nutrient … Continued

The nutrient sensor OGT in PVN neurons regulates feeding

Lagerlöf O, Slocomb JE, Hong I, Aponte Y, Blackshaw S, Hart GW, Huganir RL. Science. 2016 Mar 18;351(6279):1293-6. doi: 10.1126/science.aad5494. PMID: 26989246 Abstract Maintaining energy homeostasis is crucial for the survival and health of organisms. The brain regulates feeding by responding to … Continued

Mass Spectrometry-Based Quantitative O-GlcNAcomic Analysis

Ma J, Hart GW. Methods Mol Biol. 2016;1410:91-103. doi: 10.1007/978-1-4939-3524-6_6. PMID: 26867740 Abstract The dynamic co- and post-translational modification (PTM) of proteins, O-linked β-D-N-acetylglucosamine modification (O-GlcNAcylation) of serine/threonine residues is critical in many cellular processes, contributing to multiple physiological and pathological events. … Continued

Glucosamine induces REDD1 to suppress insulin action in retinal Müller cells

Moore JA, Miller WP, Dennis MD. Cell Signal. 2016 May;28(5):384-90. doi: 10.1016/j.cellsig.2016.01.017. PMID: 26852666 Abstract Resistance to insulin action is a key cause of diabetic complications, yet much remains unknown about the molecular mechanisms that contribute to the defect. Glucose-induced insulin resistance … Continued

QUANTITY: An Isobaric Tag for Quantitative Glycomics

Yang S, Wang M, Chen L, Yin B, Song G, Turko IV, Phinney KW, Betenbaugh MJ, Zhang H, Li S. Sci Rep. 2015 Nov 30;5:17585. doi: 10.1038/srep17585. PMID: 26616285 Abstract Glycan is an important class of macromolecules that play numerous biological functions. … Continued