Training

Opportunities in Translational Glycobiology at the BWH/Harvard PEG

Currently there are very few individuals that can place clinical medicine within the framework of glycoscience, and vice versa. The key to bridging this translational chasm is to support the development of scientists with requisite interdisciplinary knowledge and experience by providing training in glycosciences concomitantly with fundamental human biology, framed by an appreciation of human suffering and clinical urgency. To this end, the Glycosciences Skills Development Core in this PEG will traverse this gap, providing post-doctoral fellows with training in glycoscience principles and skills in concert with education in human biology and disease, thus creating “Translational Glycobiologists”.

The combination of investigators within this PEG brings a matchless ability to expose program participants to the nuances and realities of clinical issues. Two of the three project PI’s (Drs. Sackstein and Hoffmeister) are practicing clinicians in specialties directly relating to heart, lung, and blood disease. This profound clinical perspective is complemented by Dr. Lau, the third project PI, who possesses classical training in biochemistry and over 30 years of glycobiology research experience embedded within a clinical cancer center (Roswell Park Cancer Institute), thus bringing a basic science perspective to the practice of translational glycobiology.

Link to BWH/Harvard Website

Personnel

Collaborative launch of European Science Foundation (ESF) Euroglycoforum Online Lectures

Drs. Robert Sackstein and Joseph Lau presented lectures in the Glycobiology & Glycochemistry e-learning course sponsored by the European Science Foundation Euroglycoforum.  The lecture videos are currently available for online viewing and the slides are available via pdf download.

In Fall 2013 the course will be offered for credit via certification provided by the Faculty of Medical Sciences and Nova University of Lisbon.  If you are interested in learning how to obtain credit please contact Dr. Paula Videira at “paula.videira@fcm.unl.pt” or the post-graduate office “posgraduacao@fcm.unl.pt”

Lectures currently available online include:

  • NMR and molecular recognition (Dr. Barbero)
  • Biosynthesis of Glycans: Focus on the large glycosyltransferase family (Dr. Breton)
  • Mucins – their associated with carcinogenesis (Dr. Burchel)
  • Biosynthesis of cancer related carbohydrate antigens (Dr. Dall’Olio)
  • Gangliosides: Structure, Metabolism and Functions (Dr. Delannoy)
  • Glycans in pathogen-host interaction (Dr. Feizi)
  • CGD impact on families and society (Dr. Ferreira)
  • Synthesis and Bio-Functional Studies of Animal and Bacterial Glycans (Dr. Fukase)
  • Bacterial lectins and infection – from structural glycobiology to anti-adhesive strategies (Dr. Imberty)
  • Congenital Disorders of Glycosylation: an exercise in dysmorphology (Dr. Jaeken)
  • Biology of Sialyl Glycans (Dr. Lau)
  • Mammalian Innate Immunity: the role of bacterial LPS and PGN in cystic fibrosis opportunistic pathogens (Dr. Molinaro)
  • Modeling the carbohydrate field: from monosaccharides to complex architectures (Dr. Perez)
  • The stach granule: three dimensional structure and architecture (Dr. Perez)
  • Carbohydrates as raw materials for a sustainable chemistry (Dr. Queneau)
  • Glycan-mediated microbial adhesion: Hemagglutinins and Adhensins (Dr. Reis)
  • Glycoengineering of protein-based therapeutics (Dr. Ronin)
  • Glycosyltranserase-Programmed Stereosubstitution (GPS): Directing Cell Migration via Translational Glycobiology (Dr. Sackstein)
  • Basic Glycobiology Concepts (Dr. Videira)
  • Glycosylation and the immune response (Dr. Videira)
  • Glycan Biomarkers (Dr. Wandall)

Training Framework

  • Seminar Series & Yearly Symposium

  • Yearly Didactic Educational Training Sessions

  • Weekly Glycobiology Journal Club & Translational Medicine Meetings

  • Quarterly Trainee Gatherings

  • Mentored Clinical Exposure & Hands-on Skills Development in Glycoscience Techniques

Downloads

UNH Glycomics Center Retreat Slides