Integration of systems glycobiology with bioinformatics toolboxes, glycoinformatics resources, and glycoproteomics data

Liu G, Neelamegham S. Wiley Interdiscip Rev Syst Biol Med. 2015 Jul-Aug;7(4):163-81. doi: 10.1002/wsbm.1296. Review. PMID: 25871730 Abstract The glycome constitutes the entire complement of free carbohydrates and glycoconjugates expressed on whole cells or tissues. ‘Systems Glycobiology’ is an emerging discipline that … Continued

The structures of glycophorin C N-glycans, a putative component of the GPC receptor site for Plasmodium falciparum EBA-140 ligand

Ashline DJ, Duk M, Lukasiewicz J, Reinhold VN, Lisowska E, Jaskiewicz E. Glycobiology. 2015 May;25(5):570-81. doi: 10.1093/glycob/cwu188. PMID: 25552259 Abstract Glycophorins C and D are highly glycosylated integral sialoglycoproteins of human red blood cell membranes carrying the Gerbich blood group antigens. The … Continued

Tools to MSn Sequence and Document the Structures of Glycan Epitopes

Zhang H, Ashline DJ, Reinhold VN. Discov Subtleties Sugars (2013). 2014 Dec 22;2013:117-131. PMID: 27110600 Abstract Sequential disassembly (MSn) has been applied to fully characterise and document native samples containing glycan epitopes with their synthetic analogues. Both sample types were prepared by … Continued

ST3Gal-4 is the primary sialyltransferase regulating the synthesis of E-, P-, and L-selectin ligands on human myeloid leukocytes

Mondal N, Buffone A Jr, Stolfa G, Antonopoulos A, Lau JT, Haslam SM, Dell A, Neelamegham S. Blood. 2015 Jan 22;125(4):687-96. doi: 10.1182/blood-2014-07-588590. PMID: 25498912 Abstract The precise glycosyltransferase enzymes that mediate selectin-ligand biosynthesis in human leukocytes are unknown. This knowledge is … Continued