Glycoengineering of E-Selectin Ligands by Intracellular versus Extracellular Fucosylation Differentially Affects Osteotropism of Human Mesenchymal Stem Cells

Dykstra B, Lee J, Mortensen LJ, Yu H, Wu ZL, Lin CP, Rossi DJ, Sackstein R. Stem Cells. 2016 Oct;34(10):2501-2511. doi: 10.1002/stem.2435. PMID: 27335219 Abstract Human mesenchymal stem cells (MSCs) hold great promise in cellular therapeutics for skeletal diseases but lack expression … Continued

Glycans and the platelet life cycle

Li R, Hoffmeister KM, Falet H. Platelets. 2016 Sep;27(6):505-11. doi: 10.3109/09537104.2016.1171304. PMID: 27135356 Abstract Platelet numbers are intricately regulated to avoid spontaneous bleeding or arterial occlusion and organ damage. The growth factor thrombopoietin (TPO) drives platelet biogenesis by inducing megakaryocyte production. A … Continued

Fulfilling Koch’s postulates in glycoscience: HCELL, GPS and translational glycobiology

Sackstein R. Glycobiology. 2016 Jun;26(6):560-70. doi: 10.1093/glycob/cww026. Review. PMID: 26933169 Abstract Glycoscience-based research that is performed expressly to address medical necessity and improve patient outcomes is called “translational glycobiology”. In the 19th century, Robert Koch proposed a set of postulates to rigorously … Continued

Regulating billions of blood platelets: glycans and beyond

Grozovsky R, Giannini S, Falet H, Hoffmeister KM. Blood. 2015 Oct 15;126(16):1877-84. doi: 10.1182/blood-2015-01-569129. Review. PMID: 26330242 Abstract The human body produces and removes 10(11) platelets daily to maintain a normal steady state platelet count. Platelet production must be regulated to avoid … Continued

Novel mechanisms of platelet clearance and thrombopoietin regulation

Grozovsky R, Giannini S, Falet H, Hoffmeister KM. Curr Opin Hematol. 2015 Sep;22(5):445-51. doi: 10.1097/MOH.0000000000000170. Review. PMID: 26154508 Abstract PURPOSE OF REVIEW: The human body produces and removes 10 platelets daily to maintain a normal steady-state platelet count. Platelet production must be … Continued