Future GlycoGen Preview “for trainees, by trainees”

Here is a preview of abstract titles that are under review for the Future GlycoGen program — our “for trainees, by trainees” session at InterPEG-2015.

BWH/Harvard PEG

  • Using CRISPR-Cas technology to quantify the relative contributions of O-glycans, N-glycans and Glycosphingolipids to cell adhesion
  • Perturbing circulatory ST6Gal-1 levels alters granulopoiesis in-vivo
  • Unexpected exacerbation of acute airway inflammation by fucosylated-ligand deficient neutrophils
  • Maintenance of circulatory ST6Gal-1 levels requires B cells
  • Comparative Analysis of Glycoprotein Acceptors of Cell Surface Fucosylation on Human Mesenchymal Stem Cells from Marrow and and Adipose Tissue
  • In vivo demonstration of platelets remodeling membrane glycans
  • Analysis of gene expression of Glycosyltransferases in hematopoietic stem cells

Cleveland Clinic PEG

  • Disruption of hyaluronan homeostasis leads hematological defects and altered myeloid progenitor fate decisions
  • Platelet hyaluronidase-2: an enzyme that translocates to the surface upon activation to function in extracellular matrix degradation
  • Crohn’s Disease Fibroblasts, Via an IL-6 Dependent Mechanism, Selectively Overexpress the Novel Protein KIAA1199 That Cleaves Hyaluronan
  • Heparin Inhibits the Differentiation of M1 and Promotes M2 Macrophages under Hyperglycemic Stress
  • The Versican-Hyaluronan Colmplex at the Hematopoietic Stem Cell Niche is Critical for Murine Hemaopoiesis
  • Expression of Hyaluronan and has Enzymes in Primary and Immortalized Dermal Microvascular Endothelial Cells
  • O-GlcNac Transferase Directs Cell Proliferation in Idiopathic Pulmonary Arterial Hypertension
  • UVB-Induced Apoptosis in Cells from the Skin of Mice Lacking Has1 and Has3: Opposite Effects in Keratinocytes Versus Fibroblasts

CardioPEG

  • Understanding the mechanisms that lead to dynamic stress-induced O-GlcNAcylation; identification of the stress-dependent interactome of the O-GlcNAcase
  • OGT and OGA in Mitochondrial O-GlcNAc Regulation
  • Targeting Glycosyltransferase to Interfere/Alleviate Atherosclerosis and Cardiac Hypertrophy
  • Imaging of N-linked glycans from FFPE tissue sections by MALDI mass spectrometry
  • Enhanced O-GlcNAc Signaling Suppresses Peroxide-Induced Cell Death by Upreglating Autophagy
  • Deciphering the Functional O-GlcNAc Sub-Proteome
  • Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells
  • An integrated platform for glycomics and glycoproteomics
  • Protein O-GlcNAcylation regulates Mitochondrial Function
  • Spectrometric analysis of glycosphingolipid-mediated atherosclerosis

HSPG PEG

  • Role of endothelial sialic acid expression on xenogenic neutrophil adhesion
  • GAGomics: The Good, The Bad & The Ugly
  • Molecular modeling studies of non‐saccharide glycosaminoglycan mimetics selectively binding to cancer stem cell proteins
  • Exploring the conformational space of chondroitin disaccharides in explicit water using molecular dynamics simulation

LIDPEG

  • Specific subsets of kinases mediate Siglec-8 engagement-induced ROS production and apoptosis in eosinophils
  • Ligand-mediated Siglec-8 internalization in eosinophils is influenced by the actin cytoskeleton, tyrosine kinases, and sialylated cis ligands
  • Targeting inflamed endothelium with selectin-binding nanoparticles
  • Glycan ligands for targeting Siglecs on immune cells

UCSD PEG

  • Role of CD33-related Siglecs in innate immune-editing and progression of cancer
  • Oral Streptococci Utilize a Siglec-Like Domain of Serine-Rich Repeat Adhesins to Preferentially Target Platelet Sialoglycans in Human Blood
  • A unique Human Milk Oligosaccharide property promotes Group B Streptococcus death
  • Investigating the Female Specific Glycome
  • Extracellular Hsp70 Modulates Innate Immune Responses in Opposing Directions by Engaging the Paired Receptors Siglec-5 and Siglec-14
  • Role of ExtL3 in heparan sulfate biosunthesis