GSK is looking to hire a PhD to “Designing and executing studies aimed at media and feed optimization for CHO cells expressing monoclonal antibodies and gaining a detailed understanding on the mechanism and control of glycosylation of the antibody”
Potential candidates should send their resume to Udayanath.email@example.com
Uday will forward your resume to the hiring manager.
CHO-Cell Culture Media & Feed Development And its impact on mAb Production & Glycosylation
GlaxoSmithKline, Biopharmaceutical Development King of Prussia, PA
Requirements: Ph.D. in Cellular Physiology, Biochemistry or Chemical/Biochemical Engineering. Candidate must have a proven track record of scientific and technical excellence in the field of cellular physiology and metabolism. A fundamental and thorough understanding of biochemistry, techniques and assays used in biochemical analysis, sterile laboratory techniques and experience with culturing suspension adapted mammalian cells is a must. A very good functional knowledge and understanding of various analytical instruments used in biochemical assays, multivariate experimental analysis and manipulation of large sets of data is essential. Knowledge of and experience with metabolomics technology and cell culture process development is highly desired. . Additional requirements include: A very good understanding of regulations related to use of animal derived components in the manufacture of biopharmaceuticals, statistical experimental approaches viz. Multivariate analysis and Principal Component Analysis, etc.; A good understanding of electronic databases and manipulation of large data sets. The candidate must be highly motivated, have excellent organization and communication skills. The candidate must be willing to work independently within a team and matrix environment.
Description: The candidate will work in the Microbial and Cell Culture Development Department at GSK, Upper Merion, PA. The candidate will be a member of a team dedicated to Cell Culture Media & Feed Development and understanding its impact on antibody production and on product quality viz. protein glycosylation. The candidate will be expected to provide technical leadership to a team of scientists/engineers. Specific responsibilities include: Designing and executing studies aimed at media and feed optimization for CHO cells expressing monoclonal antibodies and gaining a detailed understanding on the mechanism and control of glycosylation of the antibody. Working with external vendors and collaborators. The candidate will be expected to communicate to senior management the progress made on the next generation technologies and garnering support and resources. The candidate will also be responsible for authoring and reviewing technical reports, protocols. The candidate will also be expected to interact on a routine basis with colleagues in purification process development, analytical and commercial manufacturing as well as regulatory groups. Candidate will be expected to maintain scientific excellence and provide technical leadership.
Post-doctoral fellows within GSK’s global collaborative training programme will have the opportunity to:
- Be part of cutting edge science to advance GSK’s mission ‘to improving the quality of human life by enabling people to do more, feel better, and live longer’.
- Accelerate your post-doctoral research with GSK’s extensive R&D engine.
- Bridge the gap from target identification to medicine for patients in-need by leveraging GSK’s: Tools, Technologies, Libraries, Samples, People, Knowledge Base, & Training program.
Postdoctoral research will be focused on addressing the critical R&D challenges that have been selected as cutting edge science and are optimal areas of science for post-doctoral training.
Your Postdoctoral experience will be accompanied by tremendous support at GSK with the opportunity for daily collaborations with world-class scientists. GSK is committed to providing each postdoc with a mentor who will be focused on providing a comprehensive training program and are expected to nurture skills that will enable postdocs to become independent scientific investigators.
Postdocs are actively encouraged to publish and present their research at internal and external meetings and participate in the GSK R&D postdoc community, which will include scientific and social programming. Ideal candidates will: Set direction & inspire, Work across boundaries, Release energy, Develop capabilities, Drive performance, and Live the GSK values, serving patients and consumers.