Free Webinar on Glycosylation Available

The ABCs of Glycoproteins: How to Combine Analytics, Biology, and Chemistry to Improve Your Understanding of Glycosylation

  • Broadcast Date: Friday, March 15, 2013
  • Time: 11 am ET, 8 am PT

REGISTRATION IS FREE

REGISTER NOW!

 

Many protein-based biopharmaceuticals are glycosylated proteins. The glycans themselves directly affect the efficacy and safety of the biopharmaceutical. Measurements of the sites of glycan attachment, the glycans that are present, and the relative proportions of each alternative structure are required for both pharmaceutical and regulatory reasons.

Glycosylation is the most complex post-translational protein modification. More than half of all proteins are glycosylated, and, to elucidate their function, it is important to define the structures of the glycans attached to the surface of the protein therapeutic. During therapeutic protein manufacturing process, a number of factors can have a major impact upon protein glycosylation, which is why this is a critical product attribute for therapeutic efficacy and safety. Fluctuations in the process can put product integrity at risk and therefore it is important to monitor glycosylation accurately throughout the process.

The number and similarity of possible structures of glycans place tremendous demands on the analytical techniques. Advances in analytical technology for glycan analysis, from application-dedicated chromatographic approaches to unique applications of mass spectrometry detection, to powerful informatics and processing capabilities that are referenced against a library of well-researched chromatographic retention properties, enable researchers to know more about the form and function of protein glycosylation than ever before.

 

This webinar is essential for any scientist who analyzes proteins for properties critical to therapeutic safety and efficacy. This webinar will benefit:

  • Biochemists who identify and characterize biotherapeutic proteins
  • Discovery scientists analyzing post-translational modifications of proteins
  • Development scientists involved in process optimization of cultures
  • Pharmaceutical chemists who develop formulations and test stability
  • Quality control chemists monitoring biopharmaceuticals for quality and consistency
  • Developers of follow-on biologics

Key learning points for this webinar include:

  • Role of glycan analysis in characterizing modern biotherapeutics
  • The principles of UPLC separations for glycan structures and reference resources to support the confirmation of glycan assignment
  • The practical application of a combination of UPLC, MS, informatics, and sample preparation technologies for glycan analysis in a biopharmaceutical characterization laboratory

 

A live Q&A session will follow the presentations, offering you a chance to pose questions to our expert panelists.