Glycobiology SIG Course

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Course title: Special Topics in the Glycosciences: Emerging Paradigms and Enabling Technologies

(this course is taught at NIH by members of the Glycobiology SIG)

** This course will NOT be webcast** 

Term: begins February 8, 2013

Time: sessions are from 2:00 – 4:00 p.m. on Friday’s

Format: There will be 2x 40’ lectures each session with a 10’ break between them.

Place: Building 50 (if there is enough interest we may be able to video cast to NCI Fredrick as well)

Course Description: This course will introduce the challenges and solutions to problems confronting scientists focused on decoding the “third molecular language of life.”  The training goals will include an overview of the synthesis and biological role of complex glycans, the technologies being applied to solve their complex structures, and the functional roles of glycans.

 

 

Text: Essentials of Glycobiology http://www.ncbi.nlm.nih.gov/books/NBK1908/

Other teaching materials: To be selected by each instructor (research papers, reviews or book chapters)


**There is no fee for this course**

To Register:

Send a post to “marinop@nigms.nih.gov” and provide your contact information in case we need to contact you to postpone a class due to weather/illness:

1) Your name

2) work address

3) email addy (home and work)

4) highest degree (BA/MS/PhD/MD)

5) please note if you would like to attend via video cast at NCI Fredrick

 

Lecture Topics to be covered:

  • General Principals: glycan biosynthesis and biological import
  • Human Glycosylation Disorders:  Many faces, many pathways
  • The synthesis and major biological roles of mucin-type O-glycans
  • Sialic acid synthesis, function(s), and sialic acid-related diseases
  • Bacterial polysaccharides: synthesis and function
  • The role of Carbohydrates in Innate immunity
  • The synthesis, structure and major biological actions of the proteoglycans.
  • Signaling functions of heparan sulfate proteoglycan receptors in endothelial cells and T lymphocytes
  • Lectins and enabling technologies
  • Carbohydrate-based vaccines: methods for preparing and characterizing saccharide/protein conjugates.
  • Emerging Paradigms: Nuclear and Cytoplasmic Glycosylation
  • Glycan modifications of EGF repeats and TSRs: a role in cell signaling. Notch as an example
  • Glycan array technology: a high-throughput tool to evaluate carbohydrate-protein interactions in parallel
  • Altered Glycosylation in Cancer: From Biology to Diagnostics.
  • Bioorthogonal Carbohydrate chemistry
  • Biosensors for glycan analysis
  • Mass Spectrometry, a tool for Carbohydrate Analysis: MS based analytical methods & carbohydrate fragmentation analysis
  • Using NMR to understanding carbohydrate structure and function